Frequent allelic loss of Dkk-1 locus (10q11.2) is related with low distant metastasis and better prognosis in head and neck squamous cell carcinomas

Naoki Katase, Mehmet Gunduz, Levent Bekir Beder, Esra Gunduz, Mahmoud Al Sheikh Ali, Ryo Tamamura, Kursat Oguz Yaykasli, Noboru Yamanaka, Kenji Shimizu, Hitoshi Nagatsuka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalCancer Investigation
Volume28
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • Biomarker
  • Dickkopf (Dkk)-1
  • Head and neck squamous cell carcinoma
  • Loss of heterozygosity
  • Metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Katase, N., Gunduz, M., Beder, L. B., Gunduz, E., Sheikh Ali, M. A., Tamamura, R., Yaykasli, K. O., Yamanaka, N., Shimizu, K., & Nagatsuka, H. (2010). Frequent allelic loss of Dkk-1 locus (10q11.2) is related with low distant metastasis and better prognosis in head and neck squamous cell carcinomas. Cancer Investigation, 28(1), 103-110. https://doi.org/10.3109/07357900903095680