Frequency of early and late-onset dementias in a Japanese memory disorders clinic

Osamu Yokota, K. Sasaki, Y. Fujisawa, J. Takahashi, Seishi Terada, T. Ishihara, H. Nakashima, A. Kugo, T. Ata, H. Ishizu, S. Kuroda

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Abstract

The aim of this study was to compare the diagnostic profiles of patients with early (age <65 years) and late (age ≥65 years) onset of dementia in a memory disorders clinic in Japan. A total of 512 consecutive memory clinic patients were evaluated using clinical information and results of examinations. Diagnosis of dementia was made according to DSM-III-R, and that of subtypes according to standard diagnostic criteria. A total of 464 patients met the criteria for dementia. Amongst late-onset patients (n = 430), Alzheimer's disease (AD) (48.1%) was the most frequent cause of dementia, followed by AD with cerebrovascular disease (CVD) (31.4%), vascular dementia (VaD) (9.1%), dementia with Lewy bodies (DLB) (3.7%), frontotemporal lobar degeneration (FTLD) (1.6%), and others (5.8%). On the contrary, amongst early onset patients (n = 34), the most common dementia diagnosis was AD (38.2%), followed by VaD (23.5%), FTLD (14.7%), AD with CVD (5.9%), DLB (2.9%), and others (17.6%). FTLD and VaD were significantly more common in the early onset group. All patients, but one, with DLB and Parkinson's disease dementia were late-onset. The relative frequencies of AD, VaD, and DLB in our series are consistent with epidemiologic findings in several Western countries; however, the frequency of FTLD is not consistent with the previous findings presenting high frequency in late-onset patients in some Western countries.

Original languageEnglish
Pages (from-to)782-790
Number of pages9
JournalEuropean Journal of Neurology
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 2005

Fingerprint

Memory Disorders
Dementia
Frontotemporal Lobar Degeneration
Vascular Dementia
Alzheimer Disease
Lewy Body Disease
Cerebrovascular Disorders
Diagnostic and Statistical Manual of Mental Disorders
Parkinson Disease
Japan

Keywords

  • Alzheimer's disease
  • Dementia with Lewy bodies
  • Early onset
  • Epidemiology
  • Frontotemporal dementia
  • Japan
  • Memory clinic
  • Vascular dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Frequency of early and late-onset dementias in a Japanese memory disorders clinic. / Yokota, Osamu; Sasaki, K.; Fujisawa, Y.; Takahashi, J.; Terada, Seishi; Ishihara, T.; Nakashima, H.; Kugo, A.; Ata, T.; Ishizu, H.; Kuroda, S.

In: European Journal of Neurology, Vol. 12, No. 10, 10.2005, p. 782-790.

Research output: Contribution to journalArticle

Yokota, O, Sasaki, K, Fujisawa, Y, Takahashi, J, Terada, S, Ishihara, T, Nakashima, H, Kugo, A, Ata, T, Ishizu, H & Kuroda, S 2005, 'Frequency of early and late-onset dementias in a Japanese memory disorders clinic', European Journal of Neurology, vol. 12, no. 10, pp. 782-790. https://doi.org/10.1111/j.1468-1331.2005.01072.x
Yokota, Osamu ; Sasaki, K. ; Fujisawa, Y. ; Takahashi, J. ; Terada, Seishi ; Ishihara, T. ; Nakashima, H. ; Kugo, A. ; Ata, T. ; Ishizu, H. ; Kuroda, S. / Frequency of early and late-onset dementias in a Japanese memory disorders clinic. In: European Journal of Neurology. 2005 ; Vol. 12, No. 10. pp. 782-790.
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AU - Ishihara, T.

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