Free-radical scavenging activity of radioprotectors: comparison between clinically used radioprotectors and natural antioxidants

Yoshimi Sueishi, Takumi Fujii, Risako Nii

Research output: Contribution to journalArticle

Abstract

Clinically used radioprotectors, amifostine and cysteamine, have been shown to possess free-radical scavenging activities. Natural antioxidants also possess free-radical scavenging activities, some of which have been shown to have radioprotective capability. We carried out a quantitative determination of the scavenging abilities in amifostine and cysteamine and compared the potencies with natural antioxidants by using multiple free-radical scavenging method. Overall, amifostine and cysteamine showed scavenging activity as potent as natural antioxidants. We found a correlation between scavenging activity and radioprotective efficiency that was previously determined in rat thymocytes. These correlations are indicative that natural antioxidants can be effective radioprotectors.

Original languageEnglish
Pages (from-to)695-700
Number of pages6
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume325
Issue number2
DOIs
Publication statusPublished - Aug 1 2020

Keywords

  • Antioxidant ability
  • ESR spin trapping
  • MULTIS
  • Natural antioxidant
  • Radioprotective effect

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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