Fragmented QRS is associated with torsades de pointes in patients with acquired long QT syndrome

Kayo Haraoka, Hiroshi Morita, Yukihiro Saito, Norihisa Toh, Toru Miyoshi, Nobuhiro Nishii, Satoshi Nagase, Kazufumi Nakamura, Kunihisa Kohno, Kengo F. Kusano, Kenji Kawaguchi, Tohru Ohe, Hiroshi Itoh

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background Acquired long QT syndrome (LQTS) is a disease due to a secondary repolarization abnormality induced by various predisposing factors. In contrast to congenital LQTS, risk factors that produce acquired LQTS include organic heart diseases that often exhibit depolarization abnormality. Although various repolarization parameters have been evaluated in acquired LQTS, the existence of depolarization abnormality in association with torsades de pointes (TdP) has not been reported. Objective The purpose of this study was to evaluate both repolarization (QT components) and depolarization parameters (fragmented QRS [fQRS]) in acquired LQTS patients with markedly prolonged QT interval. Methods Seventy patients with acquired severe QT prolongation (QTc

Original languageEnglish
Pages (from-to)1808-1814
Number of pages7
JournalHeart Rhythm
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 2010

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Keywords

  • Acquired long QT syndrome
  • Fragmented QRS
  • Predisposing factor
  • Repolarization reserve
  • Torsades de pointes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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