Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome

Hiroshi Morita, Kengo F. Kusano, Daiji Miura, Satoshi Nagase, Kazufumi Nakamura, Shiho T. Morita, Tohru Ohe, Douglas P. Zipes, Jiashin Wu

Research output: Contribution to journalArticle

306 Citations (Scopus)

Abstract

Background - Conduction abnormalities serve as a substrate for ventricular fibrillation (VF) in patients with Brugada syndrome (BS). Signal-averaged electrograms can detect late potentials, but the significance of conduction abnormalities within the QRS complex is still unknown. The latter can present as multiple spikes within the QRS complex (fragmented QRS [f-QRS]). We hypothesized that f-QRS could indicate a substrate for VF and might predict a high risk of VF for patients with BS. Methods and Results - In study 1, we analyzed the incidence of f-QRS in 115 patients with BS (13 resuscitated from VF, 28 with syncope, and 74 asymptomatic). f-QRS was observed in 43% of patients, more often in the VF group (incidence of f-QRS: VF 85%, syncope 50%, and asymptomatic 34%, P

Original languageEnglish
Pages (from-to)1697-1704
Number of pages8
JournalCirculation
Volume118
Issue number17
DOIs
Publication statusPublished - Oct 21 2008

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Brugada Syndrome
Ventricular Fibrillation
Syncope
Incidence

Keywords

  • Arrhythmia
  • Death, sudden
  • Electrocardiography
  • Genes
  • Tachyarrhythmias

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome. / Morita, Hiroshi; Kusano, Kengo F.; Miura, Daiji; Nagase, Satoshi; Nakamura, Kazufumi; Morita, Shiho T.; Ohe, Tohru; Zipes, Douglas P.; Wu, Jiashin.

In: Circulation, Vol. 118, No. 17, 21.10.2008, p. 1697-1704.

Research output: Contribution to journalArticle

Morita, Hiroshi ; Kusano, Kengo F. ; Miura, Daiji ; Nagase, Satoshi ; Nakamura, Kazufumi ; Morita, Shiho T. ; Ohe, Tohru ; Zipes, Douglas P. ; Wu, Jiashin. / Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome. In: Circulation. 2008 ; Vol. 118, No. 17. pp. 1697-1704.
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AU - Kusano, Kengo F.

AU - Miura, Daiji

AU - Nagase, Satoshi

AU - Nakamura, Kazufumi

AU - Morita, Shiho T.

AU - Ohe, Tohru

AU - Zipes, Douglas P.

AU - Wu, Jiashin

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KW - Death, sudden

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