Fractionation of pharmacologically active plant polyphenols by centrifugal partition chromatography

Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Kazuko Mori, Toshiyuki Fukuda

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Centrifugal partition chromatography (CPC) has been applied to the preparative fractionation of pharmacologically active polyphenols contained in the crude extracts from three medicinal plants. 1) (-)-Epigallocatechin gallate, the main component of tea polyphenols, which inhibits tumor promotion, 2) oligomeric hydrolyzable tannins, having host-mediated anti-tumor activity and antiviral activity, contained in Woodfordia fruticosa flower, 3) polyphenolic components of licorice, having anti-HIV activity. The results obtained with cartridges of medium volume and of small volume were compared during the fractionation of tea polyphenols.

Original languageEnglish
Pages (from-to)3637-3650
Number of pages14
JournalJournal of Liquid Chromatography
Volume13
Issue number18
DOIs
Publication statusPublished - Nov 1 1990

ASJC Scopus subject areas

  • Molecular Medicine

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