Fractionation of pharmacologically active plant polyphenols by centrifugal partition chromatography

Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Kazuko Mori, Toshiyuki Fukuda

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23 Citations (Scopus)


Centrifugal partition chromatography (CPC) has been applied to the preparative fractionation of pharmacologically active polyphenols contained in the crude extracts from three medicinal plants. 1) (-)-Epigallocatechin gallate, the main component of tea polyphenols, which inhibits tumor promotion, 2) oligomeric hydrolyzable tannins, having host-mediated anti-tumor activity and antiviral activity, contained in Woodfordia fruticosa flower, 3) polyphenolic components of licorice, having anti-HIV activity. The results obtained with cartridges of medium volume and of small volume were compared during the fractionation of tea polyphenols.

Original languageEnglish
Pages (from-to)3637-3650
Number of pages14
JournalJournal of Liquid Chromatography
Issue number18
Publication statusPublished - Nov 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine


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