TY - JOUR
T1 - Four new epoxy taxanes from needles of Taxus cuspidata (Taxaceae)
AU - Shi, Qing Wen
AU - Cao, Cong Mei
AU - Gu, Ji Shun
AU - Kiyota, Hiromasa
N1 - Funding Information:
The project was sponsored by the Foundation for Researching New Drugs of People’s Republic of China (No: 2003AA2Z3527) and by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of the People’s Republic of China. We thank Dr. Takayuki Oritani, Emeritus Professor of Tohoku University for his support.
PY - 2006/2
Y1 - 2006/2
N2 - Four new epoxy taxoids were isolated from the needles of Taxus cuspidata. Their structures were established as 2α,9α-diacetoxy-5α-cinnamoyloxy-11,12-epoxy-10β -hydroxytax-4(20)-en-13-one (1), 2α,10β-diacetoxy-5α -cinnamoyloxy-11,12-epoxy-9α-hydroxytax-4(20)-en-13-one (2), 2α,9α-diacetoxy-11,12-epoxy-10β,20-dihydroxytax- 4-en-13-one (3) and 2α,10β-diacetoxy-11,12-epoxy-9α,20 -dihydroxytax-4-en-13-one (4) on the basis of spectral analysis including 1H-NMR, 13C-NMR, 1H-1 H-COSY, HSQC, HMBC and HRFABMS. Compounds 3 and 4 are the first example of 11,12-epoxy taxoids with C-4 double bond found in T. cuspidata.
AB - Four new epoxy taxoids were isolated from the needles of Taxus cuspidata. Their structures were established as 2α,9α-diacetoxy-5α-cinnamoyloxy-11,12-epoxy-10β -hydroxytax-4(20)-en-13-one (1), 2α,10β-diacetoxy-5α -cinnamoyloxy-11,12-epoxy-9α-hydroxytax-4(20)-en-13-one (2), 2α,9α-diacetoxy-11,12-epoxy-10β,20-dihydroxytax- 4-en-13-one (3) and 2α,10β-diacetoxy-11,12-epoxy-9α,20 -dihydroxytax-4-en-13-one (4) on the basis of spectral analysis including 1H-NMR, 13C-NMR, 1H-1 H-COSY, HSQC, HMBC and HRFABMS. Compounds 3 and 4 are the first example of 11,12-epoxy taxoids with C-4 double bond found in T. cuspidata.
KW - 11,12-Epoxy taxanes
KW - Structure' elucidation
KW - Taxanes
KW - Taxus cuspidata
KW - Yew
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U2 - 10.1080/14786410500049426
DO - 10.1080/14786410500049426
M3 - Article
C2 - 16439348
AN - SCOPUS:30344440948
VL - 20
SP - 173
EP - 179
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
IS - 2
ER -