Abstract
Four new epoxy taxoids were isolated from the needles of Taxus cuspidata. Their structures were established as 2α,9α-diacetoxy-5α-cinnamoyloxy-11,12-epoxy-10β -hydroxytax-4(20)-en-13-one (1), 2α,10β-diacetoxy-5α -cinnamoyloxy-11,12-epoxy-9α-hydroxytax-4(20)-en-13-one (2), 2α,9α-diacetoxy-11,12-epoxy-10β,20-dihydroxytax- 4-en-13-one (3) and 2α,10β-diacetoxy-11,12-epoxy-9α,20 -dihydroxytax-4-en-13-one (4) on the basis of spectral analysis including 1H-NMR, 13C-NMR, 1H-1 H-COSY, HSQC, HMBC and HRFABMS. Compounds 3 and 4 are the first example of 11,12-epoxy taxoids with C-4 double bond found in T. cuspidata.
| Original language | English |
|---|---|
| Pages (from-to) | 173-179 |
| Number of pages | 7 |
| Journal | Natural Product Research |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2006 |
| Externally published | Yes |
Keywords
- 11,12-Epoxy taxanes
- Structure' elucidation
- Taxanes
- Taxus cuspidata
- Yew
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Plant Science
- Organic Chemistry
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Cite this
Shi, Q. W., Cao, C. M., Gu, J. S., & Kiyota, H. (2006). Four new epoxy taxanes from needles of Taxus cuspidata (Taxaceae). Natural Product Research, 20(2), 173-179. https://doi.org/10.1080/14786410500049426