Fosfomycin for the treatment of prostate infection

Hideharu Hagiya, Megumi Ninagawa, Kou Hasegawa, Tomohiro Terasaka, Kosuke Kimura, Koichi Waseda, Yoshihisa Hanayama, Toshiaki Sendo, Fumio Otsuka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 69-year-old man with diabetes mellitus was diagnosed with a prostate abscess. Although the pathogen was fluoroquinolone-resistant Escherichia coli and the oral administration of trimethoprim-sulfamethoxazole was initiated, the infection recurred after three months. The antibiotic therapy was subsequently changed to intravenous fosfomycin, and the patient’s condition promptly improved. Four weeks of fosfomycin therapy was successfully continued without any adverse events. In the era of antibiotic resistance, revival of forgotten drugs is an important issue for clinicians. Fosfomycin can be applied as an alternative option for prostate infections, considering the remaining susceptibility of multidrug-resistant pathogens to fosfomycin and the good pharmacokinetics of this drug in prostatic tissue.

Original languageEnglish
Pages (from-to)2643-2646
Number of pages4
JournalInternal Medicine
Volume53
Issue number22
DOIs
Publication statusPublished - 2014

Fingerprint

Fosfomycin
Prostate
Infection
Fluoroquinolones
Sulfamethoxazole Drug Combination Trimethoprim
Therapeutics
Microbial Drug Resistance
Pharmaceutical Preparations
Abscess
Oral Administration
Diabetes Mellitus
Pharmacokinetics
Escherichia coli
Anti-Bacterial Agents

Keywords

  • Chronic bacterial prostatitis
  • Fluoroquinolone
  • Fosfomycin
  • Prostate abscess
  • Revival of antibiotics

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Fosfomycin for the treatment of prostate infection. / Hagiya, Hideharu; Ninagawa, Megumi; Hasegawa, Kou; Terasaka, Tomohiro; Kimura, Kosuke; Waseda, Koichi; Hanayama, Yoshihisa; Sendo, Toshiaki; Otsuka, Fumio.

In: Internal Medicine, Vol. 53, No. 22, 2014, p. 2643-2646.

Research output: Contribution to journalArticle

Hagiya, Hideharu ; Ninagawa, Megumi ; Hasegawa, Kou ; Terasaka, Tomohiro ; Kimura, Kosuke ; Waseda, Koichi ; Hanayama, Yoshihisa ; Sendo, Toshiaki ; Otsuka, Fumio. / Fosfomycin for the treatment of prostate infection. In: Internal Medicine. 2014 ; Vol. 53, No. 22. pp. 2643-2646.
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