Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing

Mingyong Liu, Keqiang Chen, Teizo Yoshimura, Ying Liu, Wanghua Gong, Yingying Le, Ji Liang Gao, Jianhua Zhao, Ji Ming Wang, Aimin Wang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Wound healing is a multi-phased pathophysiological process requiring chemoattractant receptor-dependent accumulation of myeloid cells in the lesion. Two G protein-coupled formylpeptide receptors Fpr1 and Fpr2 mediate rapid neutrophil infiltration in the liver of Listeria-infected mice by sensing pathogen-derived chemotactic ligands. These receptors also recognize host-derived chemotactic peptides in inflammation and injury. Here we report the capacity of Fprs to promote the healing of sterile skin wound in mice by initiating neutrophil infiltration. We found that in normal miceneutrophils rapidly infiltrated the dermis in the wound before the production of neutrophil-specific chemokines by the injured tissue. In contrast, rapid neutrophil infiltration was markedly reduced with delayed wound closure in mice deficient in both Fprs. In addition, we detected Fpr ligand activity that chemoattracted neutrophils into the wound tissue. Our study thus demonstrates that Fprs are critical for normal healing of the sterile skin wound by mediating the first wave of neutrophil infiltration.

Original languageEnglish
Article numbere90613
JournalPLoS One
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 6 2014
Externally publishedYes

Fingerprint

tissue repair
Infiltration
Wound Healing
neutrophils
Neutrophils
animal injuries
Neutrophil Infiltration
receptors
Wounds and Injuries
Skin
Formyl Peptide Receptor
Tissue
Ligands
Listeria
skin (animal)
mice
Pathogens
Chemokines
GTP-Binding Proteins
Liver

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing. / Liu, Mingyong; Chen, Keqiang; Yoshimura, Teizo; Liu, Ying; Gong, Wanghua; Le, Yingying; Gao, Ji Liang; Zhao, Jianhua; Wang, Ji Ming; Wang, Aimin.

In: PLoS One, Vol. 9, No. 3, e90613, 06.03.2014.

Research output: Contribution to journalArticle

Liu, M, Chen, K, Yoshimura, T, Liu, Y, Gong, W, Le, Y, Gao, JL, Zhao, J, Wang, JM & Wang, A 2014, 'Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing', PLoS One, vol. 9, no. 3, e90613. https://doi.org/10.1371/journal.pone.0090613
Liu, Mingyong ; Chen, Keqiang ; Yoshimura, Teizo ; Liu, Ying ; Gong, Wanghua ; Le, Yingying ; Gao, Ji Liang ; Zhao, Jianhua ; Wang, Ji Ming ; Wang, Aimin. / Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing. In: PLoS One. 2014 ; Vol. 9, No. 3.
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