Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes

Mingyong Liu, Keqiang Chen, Teizo Yoshimura, Ying Liu, Wanghua Gong, Aimin Wang, Ji Liang Gao, Philip M. Murphy, Ji Ming Wang

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Listeria monocytogenes (Listeria) causes opportunistic infection in immunocompromised hosts with high mortality. Resistance to Listeria depends on immune responses and recruitment of neutrophils of the immune system into infected sites is an early and critical step. Mouse neutrophils express two G protein-coupled formylpeptide receptor subtypes Fpr1 and Fpr2 that recognize bacterial and host-derived chemotactic molecules including Listeria peptides for cell migration and activation. Here we report deficiency in Fprs exacerbated the severity of the infection and increased the mortality of infected mice. The mechanism involved impaired early neutrophil recruitment to the liver with Fpr1 and Fpr2 being sole receptors for neutrophils to sense Listeria chemoattractant signals and for production of bactericidal superoxide. Thus, Fprs are essential sentinels to guide the first wave of neutrophil infiltration in the liver of Listeria-infected mice for effective elimination of the invading pathogen.

Original languageEnglish
Article number786
JournalScientific Reports
Volume2
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Listeria
Listeria monocytogenes
Neutrophils
Neutrophil Infiltration
Mortality
Liver
Chemotactic Factors
Opportunistic Infections
Immunocompromised Host
G-Protein-Coupled Receptors
Superoxides
Cell Movement
Immune System
Peptides
Infection

ASJC Scopus subject areas

  • General

Cite this

Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes. / Liu, Mingyong; Chen, Keqiang; Yoshimura, Teizo; Liu, Ying; Gong, Wanghua; Wang, Aimin; Gao, Ji Liang; Murphy, Philip M.; Wang, Ji Ming.

In: Scientific Reports, Vol. 2, 786, 2012.

Research output: Contribution to journalArticle

Liu, Mingyong ; Chen, Keqiang ; Yoshimura, Teizo ; Liu, Ying ; Gong, Wanghua ; Wang, Aimin ; Gao, Ji Liang ; Murphy, Philip M. ; Wang, Ji Ming. / Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes. In: Scientific Reports. 2012 ; Vol. 2.
@article{642924849a254651a4582c9441b4458b,
title = "Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes",
abstract = "Listeria monocytogenes (Listeria) causes opportunistic infection in immunocompromised hosts with high mortality. Resistance to Listeria depends on immune responses and recruitment of neutrophils of the immune system into infected sites is an early and critical step. Mouse neutrophils express two G protein-coupled formylpeptide receptor subtypes Fpr1 and Fpr2 that recognize bacterial and host-derived chemotactic molecules including Listeria peptides for cell migration and activation. Here we report deficiency in Fprs exacerbated the severity of the infection and increased the mortality of infected mice. The mechanism involved impaired early neutrophil recruitment to the liver with Fpr1 and Fpr2 being sole receptors for neutrophils to sense Listeria chemoattractant signals and for production of bactericidal superoxide. Thus, Fprs are essential sentinels to guide the first wave of neutrophil infiltration in the liver of Listeria-infected mice for effective elimination of the invading pathogen.",
author = "Mingyong Liu and Keqiang Chen and Teizo Yoshimura and Ying Liu and Wanghua Gong and Aimin Wang and Gao, {Ji Liang} and Murphy, {Philip M.} and Wang, {Ji Ming}",
year = "2012",
doi = "10.1038/srep00786",
language = "English",
volume = "2",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes

AU - Liu, Mingyong

AU - Chen, Keqiang

AU - Yoshimura, Teizo

AU - Liu, Ying

AU - Gong, Wanghua

AU - Wang, Aimin

AU - Gao, Ji Liang

AU - Murphy, Philip M.

AU - Wang, Ji Ming

PY - 2012

Y1 - 2012

N2 - Listeria monocytogenes (Listeria) causes opportunistic infection in immunocompromised hosts with high mortality. Resistance to Listeria depends on immune responses and recruitment of neutrophils of the immune system into infected sites is an early and critical step. Mouse neutrophils express two G protein-coupled formylpeptide receptor subtypes Fpr1 and Fpr2 that recognize bacterial and host-derived chemotactic molecules including Listeria peptides for cell migration and activation. Here we report deficiency in Fprs exacerbated the severity of the infection and increased the mortality of infected mice. The mechanism involved impaired early neutrophil recruitment to the liver with Fpr1 and Fpr2 being sole receptors for neutrophils to sense Listeria chemoattractant signals and for production of bactericidal superoxide. Thus, Fprs are essential sentinels to guide the first wave of neutrophil infiltration in the liver of Listeria-infected mice for effective elimination of the invading pathogen.

AB - Listeria monocytogenes (Listeria) causes opportunistic infection in immunocompromised hosts with high mortality. Resistance to Listeria depends on immune responses and recruitment of neutrophils of the immune system into infected sites is an early and critical step. Mouse neutrophils express two G protein-coupled formylpeptide receptor subtypes Fpr1 and Fpr2 that recognize bacterial and host-derived chemotactic molecules including Listeria peptides for cell migration and activation. Here we report deficiency in Fprs exacerbated the severity of the infection and increased the mortality of infected mice. The mechanism involved impaired early neutrophil recruitment to the liver with Fpr1 and Fpr2 being sole receptors for neutrophils to sense Listeria chemoattractant signals and for production of bactericidal superoxide. Thus, Fprs are essential sentinels to guide the first wave of neutrophil infiltration in the liver of Listeria-infected mice for effective elimination of the invading pathogen.

UR - http://www.scopus.com/inward/record.url?scp=84869187758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869187758&partnerID=8YFLogxK

U2 - 10.1038/srep00786

DO - 10.1038/srep00786

M3 - Article

C2 - 23139859

AN - SCOPUS:84869187758

VL - 2

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 786

ER -