Formation of lens-like vesicles induced via microphase separations on a sorbitan monoester membrane with different headgroups

Keita Hayashi, Hideka Iwai, Toshinori Shimanouchi, Hiroshi Umakoshi, Tomoyuki Iwasaki, Ayako Kato, Hidemi Nakamura

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The microphase separation of lipid molecules on a vesicle membrane can be induced, depending on the difference in the geometric structures of their headgroups. Through cryo-transmission-electron-microscopy analysis, a lens-like vesicle was prepared by mixing 50 wt% Span 40 (sorbitan monopalmitate) and 50 wt% Tween 40 [polyoxyethylene (20) sorbitan monopalmitate]. Considering the molecular structures of Span 40 and Tween 40, the high-curvature region was mainly formed by Tween 40. As determined by Fourier-transform infrared spectroscopy, dielectric-dispersion analysis, and differential scanning calorimetry, a hydration layer was likely formed because polyoxyethylene conjugates with the headgroups of Tween 40. These investigations of the obtained self-assembled aggregates of nonionic surfactants with heterogeneous surfaces could contribute to the development of new types of biomaterials.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume135
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Microphase separation
Lenses
Polyethylene glycols
lenses
membranes
Membranes
Nonionic surfactants
Biomaterials
Hydration
Lipids
Molecular structure
Fourier transform infrared spectroscopy
hydration
lipids
Differential scanning calorimetry
Permittivity
molecular structure
heat measurement
infrared spectroscopy
surfactants

Keywords

  • Nonionic-surfactant vesicle
  • Phase separation
  • Self-assembled aggregate

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Formation of lens-like vesicles induced via microphase separations on a sorbitan monoester membrane with different headgroups. / Hayashi, Keita; Iwai, Hideka; Shimanouchi, Toshinori; Umakoshi, Hiroshi; Iwasaki, Tomoyuki; Kato, Ayako; Nakamura, Hidemi.

In: Colloids and Surfaces B: Biointerfaces, Vol. 135, 01.11.2015, p. 235-242.

Research output: Contribution to journalArticle

Hayashi, Keita ; Iwai, Hideka ; Shimanouchi, Toshinori ; Umakoshi, Hiroshi ; Iwasaki, Tomoyuki ; Kato, Ayako ; Nakamura, Hidemi. / Formation of lens-like vesicles induced via microphase separations on a sorbitan monoester membrane with different headgroups. In: Colloids and Surfaces B: Biointerfaces. 2015 ; Vol. 135. pp. 235-242.
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