Formation of lens-like vesicles induced via microphase separations on a sorbitan monoester membrane with different headgroups

Keita Hayashi, Hideka Iwai, Toshinori Shimanouchi, Hiroshi Umakoshi, Tomoyuki Iwasaki, Ayako Kato, Hidemi Nakamura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The microphase separation of lipid molecules on a vesicle membrane can be induced, depending on the difference in the geometric structures of their headgroups. Through cryo-transmission-electron-microscopy analysis, a lens-like vesicle was prepared by mixing 50 wt% Span 40 (sorbitan monopalmitate) and 50 wt% Tween 40 [polyoxyethylene (20) sorbitan monopalmitate]. Considering the molecular structures of Span 40 and Tween 40, the high-curvature region was mainly formed by Tween 40. As determined by Fourier-transform infrared spectroscopy, dielectric-dispersion analysis, and differential scanning calorimetry, a hydration layer was likely formed because polyoxyethylene conjugates with the headgroups of Tween 40. These investigations of the obtained self-assembled aggregates of nonionic surfactants with heterogeneous surfaces could contribute to the development of new types of biomaterials.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume135
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Nonionic-surfactant vesicle
  • Phase separation
  • Self-assembled aggregate

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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