Formation of directly mutagenic α-hydroxy-N-nitrosopiperidine phosphate ester by near-ultraviolet irradiation of N-nitrosopiperidine in phosphate buffer

Sakae Arimoto, Hiromi Shimada, Satoko Ukawa, Masataka Mochizuki, Hikoya Hayatsu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Previously we found that direct-acting mutagens can be formed from N-nitrosodialkylamines on exposure to near-ultraviolet light in the presence of phosphates. We have now isolated the mutagenic photoproduct formed from N-nitrosopiperidine and inorganic phosphate and identified its structure as the phosphate ester of α-hydroxy-N-nitrosopiperidine. This reaction represents a new, non-enzymatic activation of promutagenic N-nitrosodialkylamines.

Original languageEnglish
Pages (from-to)1140-1146
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume162
Issue number3
DOIs
Publication statusPublished - Aug 15 1989

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Formation of directly mutagenic α-hydroxy-N-nitrosopiperidine phosphate ester by near-ultraviolet irradiation of N-nitrosopiperidine in phosphate buffer'. Together they form a unique fingerprint.

Cite this