Abstract
Direct-acting mutagens to Salmonella typhimurium TA98 were found to be formed from heterocyclic amines on exposure to near-ultraviolet light in the presence of N-nitrosodialkylamines. We have isolated the mutagenic photoproduct formed from 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and N-nitrosodimethylamine, and the product was identified as 3-methyl-2-nitromidazo[4,5-f]quinoline (IQ(NO2)). The yield of IQ(NO2) from IQ was estimated to be 17%. Similar light-dependent activation of IQ was noted with 4 different nitrosodialkylamines other than nitrosodimethylamine. Furthermore, MeIQ and MeIQx were also activated with nitrosamine and light. These reactions represent an example of interaction between 2 different classes of mutagens.
| Original language | English |
|---|---|
| Pages (from-to) | 161-167 |
| Number of pages | 7 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 250 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- Heterocyclic amines
- IQ
- N-Nitrosodimethylamine
- Near-ultraviolet light
- Nitrosamines
ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis
Cite this
Formation of 2-nitro-3-methylimidazo[4,5-f]quinoline, a directly mutagenic product, by near-ultraviolet irradiation of a mixture of 2-amino-3-methylimidazo[4,5-f]quinoline and N-nitrosodimethylamine. / Arimoto, Sakae; Hayatsu, Hikoya.
In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 250, No. 1-2, 1991, p. 161-167.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Formation of 2-nitro-3-methylimidazo[4,5-f]quinoline, a directly mutagenic product, by near-ultraviolet irradiation of a mixture of 2-amino-3-methylimidazo[4,5-f]quinoline and N-nitrosodimethylamine
AU - Arimoto, Sakae
AU - Hayatsu, Hikoya
PY - 1991
Y1 - 1991
N2 - Direct-acting mutagens to Salmonella typhimurium TA98 were found to be formed from heterocyclic amines on exposure to near-ultraviolet light in the presence of N-nitrosodialkylamines. We have isolated the mutagenic photoproduct formed from 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and N-nitrosodimethylamine, and the product was identified as 3-methyl-2-nitromidazo[4,5-f]quinoline (IQ(NO2)). The yield of IQ(NO2) from IQ was estimated to be 17%. Similar light-dependent activation of IQ was noted with 4 different nitrosodialkylamines other than nitrosodimethylamine. Furthermore, MeIQ and MeIQx were also activated with nitrosamine and light. These reactions represent an example of interaction between 2 different classes of mutagens.
AB - Direct-acting mutagens to Salmonella typhimurium TA98 were found to be formed from heterocyclic amines on exposure to near-ultraviolet light in the presence of N-nitrosodialkylamines. We have isolated the mutagenic photoproduct formed from 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and N-nitrosodimethylamine, and the product was identified as 3-methyl-2-nitromidazo[4,5-f]quinoline (IQ(NO2)). The yield of IQ(NO2) from IQ was estimated to be 17%. Similar light-dependent activation of IQ was noted with 4 different nitrosodialkylamines other than nitrosodimethylamine. Furthermore, MeIQ and MeIQx were also activated with nitrosamine and light. These reactions represent an example of interaction between 2 different classes of mutagens.
KW - Heterocyclic amines
KW - IQ
KW - N-Nitrosodimethylamine
KW - Near-ultraviolet light
KW - Nitrosamines
UR - http://www.scopus.com/inward/record.url?scp=0025777310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025777310&partnerID=8YFLogxK
U2 - 10.1016/0027-5107(91)90172-K
DO - 10.1016/0027-5107(91)90172-K
M3 - Article
C2 - 1944331
AN - SCOPUS:0025777310
VL - 250
SP - 161
EP - 167
JO - Mutation Research
JF - Mutation Research
SN - 0027-5107
IS - 1-2
ER -