@article{83a7dfef52f148fe8da998808c98c00e,
title = "Formal total synthesis of enigmazole A",
abstract = "A stereoselective formal total synthesis of enigmazole A, a marine macrolide isolated from Cinachyrella enigmatica, is described. Lewis acid mediated intramolecular allylation of an α-acetoxy ether, prepared from alcohol and carboxylic acid fragments was carried out to construct the methylene THP ring with high stereoselectivity. The late-stage macrolactonization of the corresponding seco-acid provided a known synthetic intermediate of enigmazole A.",
keywords = "Allylation, Convergent synthesis, Enigmazole A, Macrolide, Reductive acetylation, Total synthesis",
author = "Andreas Meissner and Takayuki Kishi and Yuka Fujisawa and Yuto Murai and Hiroyoshi Takamura and Isao Kadota",
note = "Funding Information: We thank Professor A. B. Smith, III (University of Pennsylvania) for valuable discussion and suggestion. This work was financially supported by the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (No. 17K05863 ). Funding Information: We thank Professor A. B. Smith, III (University of Pennsylvania) for valuable discussion and suggestion. This work was financially supported by the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (No.17K05863). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = dec,
day = "19",
doi = "10.1016/j.tetlet.2018.11.017",
language = "English",
volume = "59",
pages = "4492--4495",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "51",
}
