An iron(II)-mediated aminohalogenation of a cyclopentenyl N-tosyloxycarbamate provided new access to the key intermediate for the synthesis of (-)-agelastatin A (AA, 1), a potent antiproliferative alkaloid. The present synthetic endeavour offered an insight into the mechanism underlying the iron(II)-mediated aminohalogenation of N-tosyloxycarbamate, in which the radical properties of the N-iron intermediates in the redox states were operative.
|Number of pages||6|
|Journal||Beilstein Journal of Organic Chemistry|
|Publication status||Published - May 3 2013|
- Free radical
- Natural product synthesis
ASJC Scopus subject areas
- Organic Chemistry