Formal hydrochromination of alkynes under nickel catalysis. Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols

Kazuhiko Takai, Shuji Sakamoto, Takahiko Isshiki, Tatsuya Kokumai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Formal hydrochromation of an alkyne leading to a 1-substituted ethenylchromium reagent is accomplished by addition of the alkyne and water to a mixture of low-valent chromium(II), a catalytic amount of nickel(II), and triphenylphosphine in DMF.

Original languageEnglish
Pages (from-to)7534-7539
Number of pages6
JournalTetrahedron
Volume62
Issue number32
DOIs
Publication statusPublished - Aug 7 2006

Fingerprint

Alkynes
Nickel
Catalysis
Aldehydes
Chromium
Water
allyl alcohol
triphenylphosphine
Low's mixture

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Formal hydrochromination of alkynes under nickel catalysis. Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols. / Takai, Kazuhiko; Sakamoto, Shuji; Isshiki, Takahiko; Kokumai, Tatsuya.

In: Tetrahedron, Vol. 62, No. 32, 07.08.2006, p. 7534-7539.

Research output: Contribution to journalArticle

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