Follicular variant of peripheral T-cell lymphoma mimicking follicular lymphoma: A case report with a review of the Literature

Naoe Goto, Hisashi Tsurumi, Michio Sawada, Nobuhiro Kanemura, Takeshi Hara, Senji Kasahara, Yusuke Kito, Katsuyoshi Takada, Yasuharu Sato, Tadashi Yoshino, Hisataka Moriwaki, Tsuyoshi Takami

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Peripheral T-cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50-year-old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3 + CD4 + CD5 + CD8 - CD10 + CD56 - CD57 - BCL6 + PD-1 + CXCL13 + and were associated with a meshwork of CD21 + follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T-cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T-helper cells.

Original languageEnglish
Pages (from-to)326-330
Number of pages5
JournalPathology International
Volume61
Issue number5
DOIs
Publication statusPublished - May 1 2011

Keywords

  • Follicular T-helper cells
  • Follicular variant PTCL
  • Phenotype

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Goto, N., Tsurumi, H., Sawada, M., Kanemura, N., Hara, T., Kasahara, S., Kito, Y., Takada, K., Sato, Y., Yoshino, T., Moriwaki, H., & Takami, T. (2011). Follicular variant of peripheral T-cell lymphoma mimicking follicular lymphoma: A case report with a review of the Literature. Pathology International, 61(5), 326-330. https://doi.org/10.1111/j.1440-1827.2011.02656.x