Focal EEG abnormalities might reflect neuropathological characteristics of pervasive developmental disorder and attention-deficit/hyperactivity disorder

Masao Kawatani, Michio Hiratani, Hiroshi Kometani, Akio Nakai, Hirokazu Tsukahara, Akemi Tomoda, Mitsufumi Mayumi, Yusei Ohshima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Neurophysiological characteristics in electroencephalograms (EEG) were investigated for patients with pervasive developmental disorder (PDD) and for patients with attention-deficit/hyperactivity disorder (AD/HD). This study examined 64 PDD children and 22 AD/HD children with no history of epilepsy or progressive neurological or psychiatric disorder. We used multivariate analysis to compare EEG abnormalities, clinical symptoms, and intelligence levels between PDD and AD/AD patient groups. Paroxysmal discharges at the frontopolar-frontal (Fp-F) brain regions and background EEG abnormalities tended to be detected preferentially in the PDD group, although paroxysmal discharges at central-temporal (C-T) regions tended to be detected preferentially in the AD/HD group. The paroxysmal discharges observed in patients expressing persistence and impulsivity are apparently localized respectively in the Fp-F and C-T regions. A combination of EEG abnormalities, including background EEG abnormalities and paroxysmal discharges at Fp-F and C-T regions, might be useful diagnostic hallmarks to distinguish PDD with AD/HD from AD/HD alone using a logistic regression model. The dysfunction of specific brain areas associated with EEG abnormalities might explain characteristics of clinical symptoms observed in PDD and AD/HD patients.

Original languageEnglish
Pages (from-to)723-730
Number of pages8
JournalBrain and Development
Volume34
Issue number9
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

Fingerprint

Attention Deficit Disorder with Hyperactivity
Electroencephalography
Temporal Lobe
Logistic Models
Impulsive Behavior
Brain
Intelligence
Psychiatry
Epilepsy
Multivariate Analysis

Keywords

  • Attention-deficit/hyperactivity disorder
  • Electroencephalogram abnormality
  • Paroxysmal discharges
  • Pervasive developmental disorder

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Pediatrics, Perinatology, and Child Health

Cite this

Focal EEG abnormalities might reflect neuropathological characteristics of pervasive developmental disorder and attention-deficit/hyperactivity disorder. / Kawatani, Masao; Hiratani, Michio; Kometani, Hiroshi; Nakai, Akio; Tsukahara, Hirokazu; Tomoda, Akemi; Mayumi, Mitsufumi; Ohshima, Yusei.

In: Brain and Development, Vol. 34, No. 9, 10.2012, p. 723-730.

Research output: Contribution to journalArticle

Kawatani, Masao ; Hiratani, Michio ; Kometani, Hiroshi ; Nakai, Akio ; Tsukahara, Hirokazu ; Tomoda, Akemi ; Mayumi, Mitsufumi ; Ohshima, Yusei. / Focal EEG abnormalities might reflect neuropathological characteristics of pervasive developmental disorder and attention-deficit/hyperactivity disorder. In: Brain and Development. 2012 ; Vol. 34, No. 9. pp. 723-730.
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