Abstract
Neurophysiological characteristics in electroencephalograms (EEG) were investigated for patients with pervasive developmental disorder (PDD) and for patients with attention-deficit/hyperactivity disorder (AD/HD). This study examined 64 PDD children and 22 AD/HD children with no history of epilepsy or progressive neurological or psychiatric disorder. We used multivariate analysis to compare EEG abnormalities, clinical symptoms, and intelligence levels between PDD and AD/AD patient groups. Paroxysmal discharges at the frontopolar-frontal (Fp-F) brain regions and background EEG abnormalities tended to be detected preferentially in the PDD group, although paroxysmal discharges at central-temporal (C-T) regions tended to be detected preferentially in the AD/HD group. The paroxysmal discharges observed in patients expressing persistence and impulsivity are apparently localized respectively in the Fp-F and C-T regions. A combination of EEG abnormalities, including background EEG abnormalities and paroxysmal discharges at Fp-F and C-T regions, might be useful diagnostic hallmarks to distinguish PDD with AD/HD from AD/HD alone using a logistic regression model. The dysfunction of specific brain areas associated with EEG abnormalities might explain characteristics of clinical symptoms observed in PDD and AD/HD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 723-730 |
| Number of pages | 8 |
| Journal | Brain and Development |
| Volume | 34 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Oct 2012 |
| Externally published | Yes |
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Keywords
- Attention-deficit/hyperactivity disorder
- Electroencephalogram abnormality
- Paroxysmal discharges
- Pervasive developmental disorder
ASJC Scopus subject areas
- Clinical Neurology
- Developmental Neuroscience
- Pediatrics, Perinatology, and Child Health
Cite this
Focal EEG abnormalities might reflect neuropathological characteristics of pervasive developmental disorder and attention-deficit/hyperactivity disorder. / Kawatani, Masao; Hiratani, Michio; Kometani, Hiroshi; Nakai, Akio; Tsukahara, Hirokazu; Tomoda, Akemi; Mayumi, Mitsufumi; Ohshima, Yusei.
In: Brain and Development, Vol. 34, No. 9, 10.2012, p. 723-730.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Focal EEG abnormalities might reflect neuropathological characteristics of pervasive developmental disorder and attention-deficit/hyperactivity disorder
AU - Kawatani, Masao
AU - Hiratani, Michio
AU - Kometani, Hiroshi
AU - Nakai, Akio
AU - Tsukahara, Hirokazu
AU - Tomoda, Akemi
AU - Mayumi, Mitsufumi
AU - Ohshima, Yusei
PY - 2012/10
Y1 - 2012/10
N2 - Neurophysiological characteristics in electroencephalograms (EEG) were investigated for patients with pervasive developmental disorder (PDD) and for patients with attention-deficit/hyperactivity disorder (AD/HD). This study examined 64 PDD children and 22 AD/HD children with no history of epilepsy or progressive neurological or psychiatric disorder. We used multivariate analysis to compare EEG abnormalities, clinical symptoms, and intelligence levels between PDD and AD/AD patient groups. Paroxysmal discharges at the frontopolar-frontal (Fp-F) brain regions and background EEG abnormalities tended to be detected preferentially in the PDD group, although paroxysmal discharges at central-temporal (C-T) regions tended to be detected preferentially in the AD/HD group. The paroxysmal discharges observed in patients expressing persistence and impulsivity are apparently localized respectively in the Fp-F and C-T regions. A combination of EEG abnormalities, including background EEG abnormalities and paroxysmal discharges at Fp-F and C-T regions, might be useful diagnostic hallmarks to distinguish PDD with AD/HD from AD/HD alone using a logistic regression model. The dysfunction of specific brain areas associated with EEG abnormalities might explain characteristics of clinical symptoms observed in PDD and AD/HD patients.
AB - Neurophysiological characteristics in electroencephalograms (EEG) were investigated for patients with pervasive developmental disorder (PDD) and for patients with attention-deficit/hyperactivity disorder (AD/HD). This study examined 64 PDD children and 22 AD/HD children with no history of epilepsy or progressive neurological or psychiatric disorder. We used multivariate analysis to compare EEG abnormalities, clinical symptoms, and intelligence levels between PDD and AD/AD patient groups. Paroxysmal discharges at the frontopolar-frontal (Fp-F) brain regions and background EEG abnormalities tended to be detected preferentially in the PDD group, although paroxysmal discharges at central-temporal (C-T) regions tended to be detected preferentially in the AD/HD group. The paroxysmal discharges observed in patients expressing persistence and impulsivity are apparently localized respectively in the Fp-F and C-T regions. A combination of EEG abnormalities, including background EEG abnormalities and paroxysmal discharges at Fp-F and C-T regions, might be useful diagnostic hallmarks to distinguish PDD with AD/HD from AD/HD alone using a logistic regression model. The dysfunction of specific brain areas associated with EEG abnormalities might explain characteristics of clinical symptoms observed in PDD and AD/HD patients.
KW - Attention-deficit/hyperactivity disorder
KW - Electroencephalogram abnormality
KW - Paroxysmal discharges
KW - Pervasive developmental disorder
UR - http://www.scopus.com/inward/record.url?scp=84865581363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865581363&partnerID=8YFLogxK
U2 - 10.1016/j.braindev.2011.11.009
DO - 10.1016/j.braindev.2011.11.009
M3 - Article
VL - 34
SP - 723
EP - 730
JO - Brain and Development
JF - Brain and Development
SN - 0387-7604
IS - 9
ER -