Focal cortical high-frequency oscillations trigger epileptic spasms: Confirmation by digital video subdural EEG

Tomoyuki Akiyama, Hiroshi Otsubo, Ayako Ochi, Taichi Ishiguro, Gemmu Kadokura, Rajesh RamachandranNair, Shelly K. Weiss, James T. Rutka, O. Carter Snead

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Objective: To localize high-frequency oscillations (HFOs) on the cortex during epileptic spasms using video subdural EEG and Multiple Band Frequency Analysis (MBFA). Methods: Using video subdural EEG sampled at 1 kHz, we studied a 14-year-old boy with asymmetric epileptic spasms of possible left frontal origin. We identified HFOs, then analyzed and localized their distributions by MBFA. We correlated HFO distribution to clinical spasm intensity. Results: Ictal subdural EEG recorded HFOs at 60-150 Hz lasting 0.3-4 s. MBFA showed extensive but noncontiguous distribution of HFOs predominantly over the left frontal and temporal regions. HFOs began and became quasiperiodic before manifestation of clinical spasms. As clinical spasms intensified, HFOs persisted in regions where they initiated subclinically but were of higher frequency and greater power than HFOs in other regions. We performed cortical resections over the left frontal and temporal regions with predominant HFOs. Six months after surgery, the patient remained seizure free. Conclusions: HFOs were present over the ictal onset zone during epileptic spasms. Periodic spasms in this patient had the characteristics of partial seizures. Significance: We show that HFOs occurred over the cerebral cortex during epileptic spasms, and we suggest that these focal cortical HFOs triggered the spasms.

Original languageEnglish
Pages (from-to)2819-2825
Number of pages7
JournalClinical Neurophysiology
Volume116
Issue number12
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

Fingerprint

Spasm
Electroencephalography
Temporal Lobe
Seizures
Stroke
Hospital Distribution Systems
Cerebral Cortex

Keywords

  • Epileptic spasms
  • High-frequency oscillation
  • Multiple band frequency analysis
  • Partial seizure
  • Subdural EEG

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Akiyama, T., Otsubo, H., Ochi, A., Ishiguro, T., Kadokura, G., RamachandranNair, R., ... Carter Snead, O. (2005). Focal cortical high-frequency oscillations trigger epileptic spasms: Confirmation by digital video subdural EEG. Clinical Neurophysiology, 116(12), 2819-2825. https://doi.org/10.1016/j.clinph.2005.08.029

Focal cortical high-frequency oscillations trigger epileptic spasms : Confirmation by digital video subdural EEG. / Akiyama, Tomoyuki; Otsubo, Hiroshi; Ochi, Ayako; Ishiguro, Taichi; Kadokura, Gemmu; RamachandranNair, Rajesh; Weiss, Shelly K.; Rutka, James T.; Carter Snead, O.

In: Clinical Neurophysiology, Vol. 116, No. 12, 12.2005, p. 2819-2825.

Research output: Contribution to journalArticle

Akiyama, T, Otsubo, H, Ochi, A, Ishiguro, T, Kadokura, G, RamachandranNair, R, Weiss, SK, Rutka, JT & Carter Snead, O 2005, 'Focal cortical high-frequency oscillations trigger epileptic spasms: Confirmation by digital video subdural EEG', Clinical Neurophysiology, vol. 116, no. 12, pp. 2819-2825. https://doi.org/10.1016/j.clinph.2005.08.029
Akiyama, Tomoyuki ; Otsubo, Hiroshi ; Ochi, Ayako ; Ishiguro, Taichi ; Kadokura, Gemmu ; RamachandranNair, Rajesh ; Weiss, Shelly K. ; Rutka, James T. ; Carter Snead, O. / Focal cortical high-frequency oscillations trigger epileptic spasms : Confirmation by digital video subdural EEG. In: Clinical Neurophysiology. 2005 ; Vol. 116, No. 12. pp. 2819-2825.
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