fMRI Activity in the Macaque Cerebellum Evoked by Intracortical Microstimulation of the Primary Somatosensory Cortex: Evidence for Polysynaptic Propagation

Teppei Matsui, Kenji W. Koyano, Keita Tamura, Takahiro Osada, Yusuke Adachi, Kentaro Miyamoto, Junichi Chikazoe, Tsukasa Kamigaki, Yasushi Miyashita

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Simultaneous electrical microstimulation (EM) and functional magnetic resonance imaging (fMRI) is a useful tool for probing connectivity across brain areas in vivo. However, it is not clear whether intracortical EM can evoke blood-oxygenation-level-dependent (BOLD) signal in areas connected polysynaptically to the stimulated site. To test for the presence of the BOLD activity evoked by polysynaptic propagation of the EM signal, we conducted simultaneous fMRI and EM in the primary somatosensory cortex (S1) of macaque monkeys. We in fact observed BOLD activations in the contralateral cerebellum which is connected to the stimulation site (i.e. S1) only through polysynaptic pathways. Furthermore, the magnitude of cerebellar activations was dependent on the current amplitude of the EM, confirming the EM is the cause of the cerebellar activations. These results suggest the importance of considering polysynaptic signal propagation, particularly via pathways including subcortical structures, for correctly interpreting 'functional connectivity' as assessed by simultaneous EM and fMRI.

Original languageEnglish
Article numbere47515
JournalPloS one
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 31 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint

Dive into the research topics of 'fMRI Activity in the Macaque Cerebellum Evoked by Intracortical Microstimulation of the Primary Somatosensory Cortex: Evidence for Polysynaptic Propagation'. Together they form a unique fingerprint.

Cite this