Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells

Hiroki Kakuta, Yukiko Koiso, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Non-peptide, small-molecular, non-competitive inhibitors of puromycin-sensitive aminopeptidase (PSA), that is, 3-(2,6-diethylphenyl)-2,4(1H,3H)-quinazolinedione (PAQ-22, 3) and its 1N-methyl analogue (MPAQ-22 4), were structurally modified to afford fluorescent bioprobes, ANTAQ (5) and DAMPAQ-22 (6). The cellular localization of PSA could be visualized by the use of these fluorescent bioprobes.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 6 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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