Fluorescence and optical-resolution photoacoustic imaging through capillary waveguides

Nicolino Stasio, Atsushi Shibukawa, Ioannis N. Papadopoulos, Salma Farahi, Olivier Simandoux, Jean Pierre Huignard, Emmanuel Bossy, Christophe Moser, Demetri Psaltis

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Endoscopy can be used to obtain high-resolution images at large depths in biological tissues. Usually endoscopic devices have a diameter ranging from 1 to few millimeters. Using digital phase conjugation, it is possible to adapt ultrathin multimode fibers to endoscopic purposes. Recently, we demonstrated that a 330 μm diameter, water-filled silica capillary waveguide can guide high frequency ultrasound waves through a 3 cm thick fat layer, allowing optical resolution photoacoustic imaging. Here we demonstrate that using digital phase conjugation, the same water-filled capillary waveguide (3 cm long) can be used as an endoscopic probe to obtain both fluorescence and optical resolution photoacoustic imaging, with no optical or acoustic elements at the tip of the waveguide. We study the consequences of using digital phase conjugation combined with a capillary waveguide and we conclude with possible future improvements of our endoscopic approach.

Original languageEnglish
Title of host publicationAdaptive Optics and Wavefront Control for Biological Systems II
EditorsSylvain Gigan, Thomas G. Bifano, Joel Kubby
ISBN (Electronic)9781628419511
Publication statusPublished - 2016
Externally publishedYes
EventAdaptive Optics and Wavefront Control for Biological Systems II - San Francisco, United States
Duration: Feb 13 2016Feb 15 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherAdaptive Optics and Wavefront Control for Biological Systems II
Country/TerritoryUnited States
CitySan Francisco


  • Wavefront shaping
  • capillary waveguides
  • digital holography
  • digital phase conjugation
  • endoscopic imaging
  • fluorescence imaging
  • photoacoustic imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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