Flow injection analysis of ascorbic acid using carriers modified with metal-porphine as oxidative solid catalyses

Akimasa Iwado, Masaki Mifune, Hiromichi Akizawa, Noriko Motohashi, Yutaka Saito

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To investigate one of practical applications of the supports modified with metal-porphines as artificial solid-catalysts, columns into which the supports were packed were supplied to catalytic columns for a flow injection analysis (FIA) system for determination of ascorbic acid (AsA) by the following reactions:AsA+O2→dehydoroAsA+H2O2,H 2O2+chromogen→2H2O+Dye.Among the columns tested, the column containing silica gels modified with Co-tetrakis(carboxyphenyl)porphine catalyzed most rapidly the oxidation reaction of AsA that is accompanied by the formation of hydrogen peroxide. The resulting hydrogen peroxide was determined by FIA system equipped with the column containing glass beads modified with Mn-tetrakis(carboxyphenyl)porphine, which gave a linear calibration curve and large peak-areas of the range corresponding to AsA concentration between 0.2 and 10 μmol/ml. The results indicated that some supports modified with metal-porphine would be applicable to the FIA for AsA as the solid catalyses which function as if the immobilized enzymes.

Original languageEnglish
Pages (from-to)1923-1928
Number of pages6
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume30
Issue number6
DOIs
Publication statusPublished - Jan 15 2003

Fingerprint

Flow Injection Analysis
Ascorbic Acid
Metals
Catalyst supports
Hydrogen Peroxide
Immobilized Enzymes
Silica Gel
Calibration
Glass
porphine
Oxidation
Catalysts

Keywords

  • Ascorbic acid
  • Catalysis
  • Flow injection analysis
  • Metal-porphine
  • Mimesis of enzyme
  • Modified carriers

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

Flow injection analysis of ascorbic acid using carriers modified with metal-porphine as oxidative solid catalyses. / Iwado, Akimasa; Mifune, Masaki; Akizawa, Hiromichi; Motohashi, Noriko; Saito, Yutaka.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 30, No. 6, 15.01.2003, p. 1923-1928.

Research output: Contribution to journalArticle

Iwado, Akimasa ; Mifune, Masaki ; Akizawa, Hiromichi ; Motohashi, Noriko ; Saito, Yutaka. / Flow injection analysis of ascorbic acid using carriers modified with metal-porphine as oxidative solid catalyses. In: Journal of Pharmaceutical and Biomedical Analysis. 2003 ; Vol. 30, No. 6. pp. 1923-1928.
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