Flavonol glucuronides and C-glucosidic ellagitannins from Melaleuca squarrosa

Morio Yoshimura, Hideyuki Ito, Kyoko Miyashita, Tsutomu Hatano, Shoko Taniguchi, Yoshiaki Amakura, Takashi Yoshida

Research output: Contribution to journalArticle

22 Citations (Scopus)


Two flavonoids and three ellagitannins, squarrosanins A, B, and C, were isolated from the leaves of Melaleuca squarrosa. The flavonoids were characterized structurally as kaempferol-3-O-(2″-O-galloyl)-glucuronide and herbacetin-3-O-glucuronide, while the ellagitannins were characterized as monomeric and dimeric C-glucosidic ellagitannins by application of spectroscopic and chemical methods. The antioxidant effect of the polyphenolic constituents of the M. squarrosa leaves was also examined in vitro, and C-glucosidic tannins including oligomers were shown to be more effective radical scavengers against 1,1-diphenyl-2-picrylhydrazyl (DPPH) than flavonoids and ordinary ellagitannins.

Original languageEnglish
Pages (from-to)3062-3069
Number of pages8
Issue number18
Publication statusPublished - Dec 2008


  • Antioxidant
  • C-Glucosidic ellagitannin
  • Flavonol glucuronide
  • Melaleuca squarrosa
  • Myrtaceae
  • Squarrosanin A
  • Squarrosanin B
  • Squarrosanin C

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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