Flavonoid metabolism: The interaction of metabolites and gut microbiota

Kaeko Murota, Yoshimasa Nakamura, Mariko Uehara

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Several dietary flavonoids exhibit anti-oxidative, anti-inflammatory, and anti-osteoporotic activities relevant to prevention of chronic diseases, including lifestyle-related diseases. Dietary flavonoids (glycoside forms) are enzymatically hydrolyzed and absorbed in the intestine, and are conjugated to their glucuronide/sulfate forms by phase II enzymes in epithelial cells and the liver. The intestinal microbiota plays an important role in the metabolism of flavonoids found in foods. Some specific products of bacterial transformation, such as ring-fission products and reduced metabolites, exhibit enhanced properties. Studies on the metabolism of flavonoids by the intestinal microbiota are crucial for understanding the role of these compounds and their impact on our health. This review focused on the metabolic pathways, bioavailability, and physiological role of flavonoids, especially metabolites of quercetin and isoflavone produced by the intestinal microbiota.

Original languageEnglish
Pages (from-to)600-610
Number of pages11
JournalBioscience, Biotechnology and Biochemistry
Volume82
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Metabolites
Flavonoids
Metabolism
Bacterial Transformation
Isoflavones
Fission products
Quercetin
Glucuronides
Glycosides
Metabolic Networks and Pathways
Liver
Biological Availability
Sulfates
Intestines
Life Style
Chronic Disease
Anti-Inflammatory Agents
Epithelial Cells
Gastrointestinal Microbiome
Health

Keywords

  • Equol
  • Flavonoid
  • Microbial metabolism
  • Phase II metabolism
  • Ring-fission products

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Flavonoid metabolism : The interaction of metabolites and gut microbiota. / Murota, Kaeko; Nakamura, Yoshimasa; Uehara, Mariko.

In: Bioscience, Biotechnology and Biochemistry, Vol. 82, No. 4, 01.01.2018, p. 600-610.

Research output: Contribution to journalReview article

@article{9f041a956fe647fcacda56050305dcc2,
title = "Flavonoid metabolism: The interaction of metabolites and gut microbiota",
abstract = "Several dietary flavonoids exhibit anti-oxidative, anti-inflammatory, and anti-osteoporotic activities relevant to prevention of chronic diseases, including lifestyle-related diseases. Dietary flavonoids (glycoside forms) are enzymatically hydrolyzed and absorbed in the intestine, and are conjugated to their glucuronide/sulfate forms by phase II enzymes in epithelial cells and the liver. The intestinal microbiota plays an important role in the metabolism of flavonoids found in foods. Some specific products of bacterial transformation, such as ring-fission products and reduced metabolites, exhibit enhanced properties. Studies on the metabolism of flavonoids by the intestinal microbiota are crucial for understanding the role of these compounds and their impact on our health. This review focused on the metabolic pathways, bioavailability, and physiological role of flavonoids, especially metabolites of quercetin and isoflavone produced by the intestinal microbiota.",
keywords = "Equol, Flavonoid, Microbial metabolism, Phase II metabolism, Ring-fission products",
author = "Kaeko Murota and Yoshimasa Nakamura and Mariko Uehara",
year = "2018",
month = "1",
day = "1",
doi = "10.1080/09168451.2018.1444467",
language = "English",
volume = "82",
pages = "600--610",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "4",

}

TY - JOUR

T1 - Flavonoid metabolism

T2 - The interaction of metabolites and gut microbiota

AU - Murota, Kaeko

AU - Nakamura, Yoshimasa

AU - Uehara, Mariko

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Several dietary flavonoids exhibit anti-oxidative, anti-inflammatory, and anti-osteoporotic activities relevant to prevention of chronic diseases, including lifestyle-related diseases. Dietary flavonoids (glycoside forms) are enzymatically hydrolyzed and absorbed in the intestine, and are conjugated to their glucuronide/sulfate forms by phase II enzymes in epithelial cells and the liver. The intestinal microbiota plays an important role in the metabolism of flavonoids found in foods. Some specific products of bacterial transformation, such as ring-fission products and reduced metabolites, exhibit enhanced properties. Studies on the metabolism of flavonoids by the intestinal microbiota are crucial for understanding the role of these compounds and their impact on our health. This review focused on the metabolic pathways, bioavailability, and physiological role of flavonoids, especially metabolites of quercetin and isoflavone produced by the intestinal microbiota.

AB - Several dietary flavonoids exhibit anti-oxidative, anti-inflammatory, and anti-osteoporotic activities relevant to prevention of chronic diseases, including lifestyle-related diseases. Dietary flavonoids (glycoside forms) are enzymatically hydrolyzed and absorbed in the intestine, and are conjugated to their glucuronide/sulfate forms by phase II enzymes in epithelial cells and the liver. The intestinal microbiota plays an important role in the metabolism of flavonoids found in foods. Some specific products of bacterial transformation, such as ring-fission products and reduced metabolites, exhibit enhanced properties. Studies on the metabolism of flavonoids by the intestinal microbiota are crucial for understanding the role of these compounds and their impact on our health. This review focused on the metabolic pathways, bioavailability, and physiological role of flavonoids, especially metabolites of quercetin and isoflavone produced by the intestinal microbiota.

KW - Equol

KW - Flavonoid

KW - Microbial metabolism

KW - Phase II metabolism

KW - Ring-fission products

UR - http://www.scopus.com/inward/record.url?scp=85044997455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044997455&partnerID=8YFLogxK

U2 - 10.1080/09168451.2018.1444467

DO - 10.1080/09168451.2018.1444467

M3 - Review article

C2 - 29504827

AN - SCOPUS:85044997455

VL - 82

SP - 600

EP - 610

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 4

ER -