Flavan dimers with lipase inhibitory activity from Cassia nomame

Tsutomu Hatano, Akiko Yamashita, Toshitaka Hashimoto, Hideyuki Ito, Naoki Kubo, Masaaki Yoshiyama, Susumu Shimura, Yoshio Itoh, Takuo Okuda, Takashi Yoshida

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Five flavan dimers which showed lipase-inhibiting effects were isolated from fruits of Cassia nomame (Leguminosae). Structures of two new compounds among them were determined to be (2S)-3',4',7-trihydroxyflavan-(4β→8)- catechin and (2S)-3',4',7-trihydroxyflavan-(4α→8)-catechin. Four flavan dimers structurally related to these two compounds were also synthesized for spectral comparison. Among 10 flavan dimers tested for lipase-inhibitory activity, (2S)-3',4',7-trihydroxyflavan-(4α→8)-catechin showed the most potent inhibitory effect. A partially purified fraction composed of oligomeric flavans with M(n) 1020 also showed a noticeable inhibitory effect.

Original languageEnglish
Pages (from-to)893-900
Number of pages8
JournalPhytochemistry
Volume46
Issue number5
DOIs
Publication statusPublished - Nov 1997

Fingerprint

Cassia
Catechin
catechin
Lipase
Dimers
Fruits
Fabaceae
Fruit
fruits
Chamaecrista dimidiata

Keywords

  • Cassia nomame
  • Flavan dimer
  • Leguminosae
  • Lipase inhibitor
  • Oligomeric flavanoid
  • Tannin

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

Hatano, T., Yamashita, A., Hashimoto, T., Ito, H., Kubo, N., Yoshiyama, M., ... Yoshida, T. (1997). Flavan dimers with lipase inhibitory activity from Cassia nomame. Phytochemistry, 46(5), 893-900. https://doi.org/10.1016/S0031-9422(97)00367-1

Flavan dimers with lipase inhibitory activity from Cassia nomame. / Hatano, Tsutomu; Yamashita, Akiko; Hashimoto, Toshitaka; Ito, Hideyuki; Kubo, Naoki; Yoshiyama, Masaaki; Shimura, Susumu; Itoh, Yoshio; Okuda, Takuo; Yoshida, Takashi.

In: Phytochemistry, Vol. 46, No. 5, 11.1997, p. 893-900.

Research output: Contribution to journalArticle

Hatano, T, Yamashita, A, Hashimoto, T, Ito, H, Kubo, N, Yoshiyama, M, Shimura, S, Itoh, Y, Okuda, T & Yoshida, T 1997, 'Flavan dimers with lipase inhibitory activity from Cassia nomame', Phytochemistry, vol. 46, no. 5, pp. 893-900. https://doi.org/10.1016/S0031-9422(97)00367-1
Hatano T, Yamashita A, Hashimoto T, Ito H, Kubo N, Yoshiyama M et al. Flavan dimers with lipase inhibitory activity from Cassia nomame. Phytochemistry. 1997 Nov;46(5):893-900. https://doi.org/10.1016/S0031-9422(97)00367-1
Hatano, Tsutomu ; Yamashita, Akiko ; Hashimoto, Toshitaka ; Ito, Hideyuki ; Kubo, Naoki ; Yoshiyama, Masaaki ; Shimura, Susumu ; Itoh, Yoshio ; Okuda, Takuo ; Yoshida, Takashi. / Flavan dimers with lipase inhibitory activity from Cassia nomame. In: Phytochemistry. 1997 ; Vol. 46, No. 5. pp. 893-900.
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