FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus

Yun Fei Lu, Yasushi Hayashi, Akiyoshi Moriwaki, Kazuhito Tomizawa, Hideki Matsui

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32 Citations (Scopus)


The effects of FK506, a Ca2+/calmodulin-dependent phosphatase 2B (calcineurin) inhibitor, on the synaptic potentials and long-term potentiation (LTP) were investigated, using extracellular recordings in the CA1 region of adult rat hippocampal slices. Bath application of FK506 (1-50 μM) produced a dose-dependent and reversible inhibition on the field excitatory postsynaptic potentials. FK506 also showed an inhibitory effect on the induction of LTP evoked by theta-burst stimulation. Analyses of the fiber volley and paired-pulse facilitation revealed that FK506-induced effects were based on postsynaptic mechanisms. These results demonstrate that FK506 inhibits both the synaptic transmission and the LTP induction, and suggest that calcineurin plays a promoting role in the LTP processes in the hippocampus of adult rats.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalNeuroscience Letters
Issue number2
Publication statusPublished - Feb 23 1996


  • Calcineurin
  • FK506
  • Fiber volley
  • Hippocampus
  • Long-term potentiation
  • Paired-pulse facilitation
  • Protein phosphatase
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)


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