Fishy tales of prolactin-releasing peptide

Tatsuya Sakamoto, Masaaki Fujimoto, Masaaki Ando

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Prolactin (PRL) is an important regulator of multiple biological functions, but a specific PRL-releasing factor, PRL-releasing peptide (PrRP), was isolated only recently from mammals and teleosts. Although this peptide seems to be a strong candidate for being a physiologically relevant stimulator of PRL expression and secretion in teleost pituitary and peripheral organs, it may not be a typical or classic hypothalamic releasing factor in rats. We now know that its biological actions are not limited solely to PRL stimulation, because it is also a neuromodulator of several hypothalamus-pituitary axes and is involved in some brain circuits with the regulation of food intake and cardiovascular functions. Moreover, it plays a direct role in hypertension and retinal information processing. It is the purpose of this review to provide a comprehensive survey of our current knowledge of PrRP and to provide a comparative point of view.

Original languageEnglish
Pages (from-to)91-130
Number of pages40
JournalInternational Review of Cytology
Volume225
DOIs
Publication statusPublished - 2003

Fingerprint

Prolactin-Releasing Hormone
Prolactin
Pituitary Hormone-Releasing Hormones
Appetite Regulation
Peptides
Mammals
Automatic Data Processing
Hypothalamus
Neurotransmitter Agents
Rats
Brain
Hypertension
Networks (circuits)

Keywords

  • Autonomic function
  • Brain
  • Hypothalamus-pituitary
  • Neuroscience
  • Prolactin
  • Prolactin-releasing peptide
  • Prolactin-releasing peptide receptor
  • Teleost fish

ASJC Scopus subject areas

  • Cell Biology
  • Histology

Cite this

Fishy tales of prolactin-releasing peptide. / Sakamoto, Tatsuya; Fujimoto, Masaaki; Ando, Masaaki.

In: International Review of Cytology, Vol. 225, 2003, p. 91-130.

Research output: Contribution to journalArticle

Sakamoto, Tatsuya ; Fujimoto, Masaaki ; Ando, Masaaki. / Fishy tales of prolactin-releasing peptide. In: International Review of Cytology. 2003 ; Vol. 225. pp. 91-130.
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