Abstract
Prolactin (PRL) is an important regulator of multiple biological functions, but a specific PRL-releasing factor, PRL-releasing peptide (PrRP), was isolated only recently from mammals and teleosts. Although this peptide seems to be a strong candidate for being a physiologically relevant stimulator of PRL expression and secretion in teleost pituitary and peripheral organs, it may not be a typical or classic hypothalamic releasing factor in rats. We now know that its biological actions are not limited solely to PRL stimulation, because it is also a neuromodulator of several hypothalamus-pituitary axes and is involved in some brain circuits with the regulation of food intake and cardiovascular functions. Moreover, it plays a direct role in hypertension and retinal information processing. It is the purpose of this review to provide a comprehensive survey of our current knowledge of PrRP and to provide a comparative point of view.
| Original language | English |
|---|---|
| Pages (from-to) | 91-130 |
| Number of pages | 40 |
| Journal | International Review of Cytology |
| Volume | 225 |
| DOIs | |
| Publication status | Published - 2003 |
Fingerprint
Keywords
- Autonomic function
- Brain
- Hypothalamus-pituitary
- Neuroscience
- Prolactin
- Prolactin-releasing peptide
- Prolactin-releasing peptide receptor
- Teleost fish
ASJC Scopus subject areas
- Cell Biology
- Histology
Cite this
Fishy tales of prolactin-releasing peptide. / Sakamoto, Tatsuya; Fujimoto, Masaaki; Ando, Masaaki.
In: International Review of Cytology, Vol. 225, 2003, p. 91-130.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fishy tales of prolactin-releasing peptide
AU - Sakamoto, Tatsuya
AU - Fujimoto, Masaaki
AU - Ando, Masaaki
PY - 2003
Y1 - 2003
N2 - Prolactin (PRL) is an important regulator of multiple biological functions, but a specific PRL-releasing factor, PRL-releasing peptide (PrRP), was isolated only recently from mammals and teleosts. Although this peptide seems to be a strong candidate for being a physiologically relevant stimulator of PRL expression and secretion in teleost pituitary and peripheral organs, it may not be a typical or classic hypothalamic releasing factor in rats. We now know that its biological actions are not limited solely to PRL stimulation, because it is also a neuromodulator of several hypothalamus-pituitary axes and is involved in some brain circuits with the regulation of food intake and cardiovascular functions. Moreover, it plays a direct role in hypertension and retinal information processing. It is the purpose of this review to provide a comprehensive survey of our current knowledge of PrRP and to provide a comparative point of view.
AB - Prolactin (PRL) is an important regulator of multiple biological functions, but a specific PRL-releasing factor, PRL-releasing peptide (PrRP), was isolated only recently from mammals and teleosts. Although this peptide seems to be a strong candidate for being a physiologically relevant stimulator of PRL expression and secretion in teleost pituitary and peripheral organs, it may not be a typical or classic hypothalamic releasing factor in rats. We now know that its biological actions are not limited solely to PRL stimulation, because it is also a neuromodulator of several hypothalamus-pituitary axes and is involved in some brain circuits with the regulation of food intake and cardiovascular functions. Moreover, it plays a direct role in hypertension and retinal information processing. It is the purpose of this review to provide a comprehensive survey of our current knowledge of PrRP and to provide a comparative point of view.
KW - Autonomic function
KW - Brain
KW - Hypothalamus-pituitary
KW - Neuroscience
KW - Prolactin
KW - Prolactin-releasing peptide
KW - Prolactin-releasing peptide receptor
KW - Teleost fish
UR - http://www.scopus.com/inward/record.url?scp=0037262281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037262281&partnerID=8YFLogxK
U2 - 10.1016/S0074-7696(05)25003-9
DO - 10.1016/S0074-7696(05)25003-9
M3 - Article
C2 - 12696591
AN - SCOPUS:0037262281
VL - 225
SP - 91
EP - 130
JO - International Review of Cell and Molecular Biology
JF - International Review of Cell and Molecular Biology
SN - 1937-6448
ER -