Fishy tales of prolactin-releasing peptide

Tatsuya Sakamoto, Masaaki Fujimoto, Masaaki Ando

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Prolactin (PRL) is an important regulator of multiple biological functions, but a specific PRL-releasing factor, PRL-releasing peptide (PrRP), was isolated only recently from mammals and teleosts. Although this peptide seems to be a strong candidate for being a physiologically relevant stimulator of PRL expression and secretion in teleost pituitary and peripheral organs, it may not be a typical or classic hypothalamic releasing factor in rats. We now know that its biological actions are not limited solely to PRL stimulation, because it is also a neuromodulator of several hypothalamus-pituitary axes and is involved in some brain circuits with the regulation of food intake and cardiovascular functions. Moreover, it plays a direct role in hypertension and retinal information processing. It is the purpose of this review to provide a comprehensive survey of our current knowledge of PrRP and to provide a comparative point of view.

Original languageEnglish
Pages (from-to)91-130
Number of pages40
JournalInternational Review of Cytology
Volume225
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Autonomic function
  • Brain
  • Hypothalamus-pituitary
  • Neuroscience
  • Prolactin
  • Prolactin-releasing peptide
  • Prolactin-releasing peptide receptor
  • Teleost fish

ASJC Scopus subject areas

  • Histology
  • Cell Biology

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