First Total Synthesis of Reassigned Echinosulfonic Acid D

Takumi Abe, Ren Nakajima, Toshiki Yamashiro, Daisuke Sawada

Research output: Contribution to journalArticlepeer-review

Abstract

Echinosulfonic acid D, a sponge metabolite whose structure was recently reassigned, was synthesized for the first time. The key step is the double indolization of dimethylbarbituric acid using the umpolung indole reagent, followed by a hydrolysis/decarboxylation/esterification sequence.

Original languageEnglish
Pages (from-to)2122-2125
Number of pages4
JournalJournal of Natural Products
Volume85
Issue number8
DOIs
Publication statusPublished - Aug 26 2022

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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