First synthesis and absolute configuration of (-)-pyriculariol, a phytotoxin isolated from rice blast fungus, Magnaporthe grisea. Use of microwave irradiation to control Stille coupling reaction products

Ayaka Sasaki, Koji Tanaka, Yuuki Sato, Shigefumi Kuwahara, Hiromasa Kiyota

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7 Citations (Scopus)

Abstract

First total synthesis of (-)-pyriculariol, a phytotoxin isolated from rice blast fungus, Magnaporthe grisea, was achieved to determine the absolute configuration of the natural product to be 5′R,6′S. The key step was Stille coupling reaction using microwave irradiation from -78 °C to control the reaction.

Original languageEnglish
Pages (from-to)4637-4638
Number of pages2
JournalTetrahedron Letters
Volume50
Issue number32
DOIs
Publication statusPublished - Aug 12 2009

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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