Fine deletional mapping of chromosome 4q22-35 region in oral cancer.

Yasuo Shinno, Esra Gunduz, Mehmet Gunduz, Hitoshi Nagatsuka, Hidetsugu Tsujigiwa, Beyhan Cengiz, You Jin Lee, Ryo Tamamura, Mamoru Oouchida, Kunihiro Fukushima, Kenji Shimizu, Noriyuki Nagai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We analyzed the loss of heterozygosity of the long arm of chromosome 4 in 40 oral cancers, using 16 microsatellite markers based on data from the human genome sequence, and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers, D4S2623 and D4S1644, with an allelic deletion of 44 and 39%, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5 Mbp around the marker, D4S2623. Caspase 6 is localized 280 kb from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggests caspase 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalInternational Journal of Molecular Medicine
Volume16
Issue number1
Publication statusPublished - Jul 2005

Fingerprint

Caspase 6
Chromosome Mapping
Mouth Neoplasms
Tumor Suppressor Genes
Chromosomes, Human, Pair 4
Loss of Heterozygosity
Human Genome
Microsatellite Repeats
Carcinogenesis

ASJC Scopus subject areas

  • Genetics

Cite this

Shinno, Y., Gunduz, E., Gunduz, M., Nagatsuka, H., Tsujigiwa, H., Cengiz, B., ... Nagai, N. (2005). Fine deletional mapping of chromosome 4q22-35 region in oral cancer. International Journal of Molecular Medicine, 16(1), 93-98.

Fine deletional mapping of chromosome 4q22-35 region in oral cancer. / Shinno, Yasuo; Gunduz, Esra; Gunduz, Mehmet; Nagatsuka, Hitoshi; Tsujigiwa, Hidetsugu; Cengiz, Beyhan; Lee, You Jin; Tamamura, Ryo; Oouchida, Mamoru; Fukushima, Kunihiro; Shimizu, Kenji; Nagai, Noriyuki.

In: International Journal of Molecular Medicine, Vol. 16, No. 1, 07.2005, p. 93-98.

Research output: Contribution to journalArticle

Shinno, Y, Gunduz, E, Gunduz, M, Nagatsuka, H, Tsujigiwa, H, Cengiz, B, Lee, YJ, Tamamura, R, Oouchida, M, Fukushima, K, Shimizu, K & Nagai, N 2005, 'Fine deletional mapping of chromosome 4q22-35 region in oral cancer.', International Journal of Molecular Medicine, vol. 16, no. 1, pp. 93-98.
Shinno, Yasuo ; Gunduz, Esra ; Gunduz, Mehmet ; Nagatsuka, Hitoshi ; Tsujigiwa, Hidetsugu ; Cengiz, Beyhan ; Lee, You Jin ; Tamamura, Ryo ; Oouchida, Mamoru ; Fukushima, Kunihiro ; Shimizu, Kenji ; Nagai, Noriyuki. / Fine deletional mapping of chromosome 4q22-35 region in oral cancer. In: International Journal of Molecular Medicine. 2005 ; Vol. 16, No. 1. pp. 93-98.
@article{ecc19385847f420aa60d44b21fca9470,
title = "Fine deletional mapping of chromosome 4q22-35 region in oral cancer.",
abstract = "We analyzed the loss of heterozygosity of the long arm of chromosome 4 in 40 oral cancers, using 16 microsatellite markers based on data from the human genome sequence, and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers, D4S2623 and D4S1644, with an allelic deletion of 44 and 39{\%}, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5 Mbp around the marker, D4S2623. Caspase 6 is localized 280 kb from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggests caspase 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.",
author = "Yasuo Shinno and Esra Gunduz and Mehmet Gunduz and Hitoshi Nagatsuka and Hidetsugu Tsujigiwa and Beyhan Cengiz and Lee, {You Jin} and Ryo Tamamura and Mamoru Oouchida and Kunihiro Fukushima and Kenji Shimizu and Noriyuki Nagai",
year = "2005",
month = "7",
language = "English",
volume = "16",
pages = "93--98",
journal = "International Journal of Molecular Medicine",
issn = "1107-3756",
publisher = "Spandidos Publications",
number = "1",

}

TY - JOUR

T1 - Fine deletional mapping of chromosome 4q22-35 region in oral cancer.

AU - Shinno, Yasuo

AU - Gunduz, Esra

AU - Gunduz, Mehmet

AU - Nagatsuka, Hitoshi

AU - Tsujigiwa, Hidetsugu

AU - Cengiz, Beyhan

AU - Lee, You Jin

AU - Tamamura, Ryo

AU - Oouchida, Mamoru

AU - Fukushima, Kunihiro

AU - Shimizu, Kenji

AU - Nagai, Noriyuki

PY - 2005/7

Y1 - 2005/7

N2 - We analyzed the loss of heterozygosity of the long arm of chromosome 4 in 40 oral cancers, using 16 microsatellite markers based on data from the human genome sequence, and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers, D4S2623 and D4S1644, with an allelic deletion of 44 and 39%, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5 Mbp around the marker, D4S2623. Caspase 6 is localized 280 kb from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggests caspase 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.

AB - We analyzed the loss of heterozygosity of the long arm of chromosome 4 in 40 oral cancers, using 16 microsatellite markers based on data from the human genome sequence, and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers, D4S2623 and D4S1644, with an allelic deletion of 44 and 39%, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5 Mbp around the marker, D4S2623. Caspase 6 is localized 280 kb from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggests caspase 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.

UR - http://www.scopus.com/inward/record.url?scp=33644655827&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644655827&partnerID=8YFLogxK

M3 - Article

C2 - 15942683

AN - SCOPUS:33644655827

VL - 16

SP - 93

EP - 98

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

IS - 1

ER -