Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer

Beyhan Cengiz, Mehmet Gunduz, Hitoshi Nagatsuka, Levent Beder, Esra Gunduz, Ryo Tamamura, Naila Mahmut, Kunihiro Fukushima, Mahmoud Al Sheikh Ali, Yoshio Naomoto, Kenji Shimizu, Noriyuki Nagai

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalOral Oncology
Volume43
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • 2q
  • 2q21-24
  • 2q33-35
  • 2q37.3
  • CASP8
  • ING5
  • Loss of heterozygosity
  • Oral cancer

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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  • Cite this

    Cengiz, B., Gunduz, M., Nagatsuka, H., Beder, L., Gunduz, E., Tamamura, R., Mahmut, N., Fukushima, K., Ali, M. A. S., Naomoto, Y., Shimizu, K., & Nagai, N. (2007). Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer. Oral Oncology, 43(3), 241-247. https://doi.org/10.1016/j.oraloncology.2006.03.004