TY - JOUR
T1 - Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer
AU - Cengiz, Beyhan
AU - Gunduz, Mehmet
AU - Nagatsuka, Hitoshi
AU - Beder, Levent
AU - Gunduz, Esra
AU - Tamamura, Ryo
AU - Mahmut, Naila
AU - Fukushima, Kunihiro
AU - Ali, Mahmoud Al Sheikh
AU - Naomoto, Yoshio
AU - Shimizu, Kenji
AU - Nagai, Noriyuki
N1 - Funding Information:
This work was partially supported by grants-in-aid for scientific researches from the Ministry of Education, Culture, Sports, Science and Technology (#17591911, 17591910, 15209060, 17406027).
PY - 2007/3
Y1 - 2007/3
N2 - We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.
AB - We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.
KW - 2q
KW - 2q21-24
KW - 2q33-35
KW - 2q37.3
KW - CASP8
KW - ING5
KW - Loss of heterozygosity
KW - Oral cancer
UR - http://www.scopus.com/inward/record.url?scp=33846887596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846887596&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2006.03.004
DO - 10.1016/j.oraloncology.2006.03.004
M3 - Article
C2 - 16857411
AN - SCOPUS:33846887596
VL - 43
SP - 241
EP - 247
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 3
ER -
