Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer

Beyhan Cengiz; Mehmet Gunduz; Hitoshi Nagatsuka; Levent Beder; Esra Gunduz; Ryo Tamamura; Naila Mahmut; Kunihiro Fukushima; Mahmoud Al Sheikh Ali; Yoshio Naomoto; Kenji Shimizu; Noriyuki Nagai

doi:10.1016/j.oraloncology.2006.03.004

Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer

Beyhan Cengiz, Mehmet Gunduz, Hitoshi Nagatsuka, Levent Beder, Esra Gunduz, Ryo Tamamura, Naila Mahmut, Kunihiro Fukushima, Mahmoud Al Sheikh Ali, Yoshio Naomoto, Kenji Shimizu, Noriyuki Nagai

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.

Original language	English
Pages (from-to)	241-247
Number of pages	7
Journal	Oral Oncology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.oraloncology.2006.03.004
Publication status	Published - Mar 2007

Keywords

2q
2q21-24
2q33-35
2q37.3
CASP8
ING5
Loss of heterozygosity
Oral cancer

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2006.03.004

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Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer. / Cengiz, Beyhan; Gunduz, Mehmet; Nagatsuka, Hitoshi; Beder, Levent; Gunduz, Esra; Tamamura, Ryo; Mahmut, Naila; Fukushima, Kunihiro; Ali, Mahmoud Al Sheikh; Naomoto, Yoshio; Shimizu, Kenji; Nagai, Noriyuki.

In: Oral Oncology, Vol. 43, No. 3, 03.2007, p. 241-247.

Research output: Contribution to journal › Article › peer-review

Cengiz, Beyhan ; Gunduz, Mehmet ; Nagatsuka, Hitoshi ; Beder, Levent ; Gunduz, Esra ; Tamamura, Ryo ; Mahmut, Naila ; Fukushima, Kunihiro ; Ali, Mahmoud Al Sheikh ; Naomoto, Yoshio ; Shimizu, Kenji ; Nagai, Noriyuki. / Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer. In: Oral Oncology. 2007 ; Vol. 43, No. 3. pp. 241-247.

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title = "Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer",

abstract = "We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.",

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author = "Beyhan Cengiz and Mehmet Gunduz and Hitoshi Nagatsuka and Levent Beder and Esra Gunduz and Ryo Tamamura and Naila Mahmut and Kunihiro Fukushima and Ali, {Mahmoud Al Sheikh} and Yoshio Naomoto and Kenji Shimizu and Noriyuki Nagai",

note = "Funding Information: This work was partially supported by grants-in-aid for scientific researches from the Ministry of Education, Culture, Sports, Science and Technology (#17591911, 17591910, 15209060, 17406027).",

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doi = "10.1016/j.oraloncology.2006.03.004",

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AU - Cengiz, Beyhan

AU - Gunduz, Mehmet

AU - Nagatsuka, Hitoshi

AU - Beder, Levent

AU - Gunduz, Esra

AU - Tamamura, Ryo

AU - Mahmut, Naila

AU - Fukushima, Kunihiro

AU - Ali, Mahmoud Al Sheikh

AU - Naomoto, Yoshio

AU - Shimizu, Kenji

AU - Nagai, Noriyuki

N1 - Funding Information: This work was partially supported by grants-in-aid for scientific researches from the Ministry of Education, Culture, Sports, Science and Technology (#17591911, 17591910, 15209060, 17406027).

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N2 - We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.

AB - We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.

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Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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