Fibrillary glomerulonephritis in a patient with familial sensorineural deafness

Haruo Ichikawa, Shuji Ikeda, Masami Hashimoto, Yoshio Nagake, Kazue Hironaka, Kenichi Shikata, Hirofumi Makino

Research output: Contribution to journalArticle

Abstract

A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalNephrology
Volume3
Issue number4
Publication statusPublished - 1997

Fingerprint

Deafness
Glomerulonephritis
Microfibrils
Kidney
Cryoglobulinemia
Congo Red
Paraproteinemias
Proteinuria
Amyloid
Systemic Lupus Erythematosus
Staining and Labeling
Biopsy
Light

Keywords

  • Electron microscopy
  • Familial sensorineural deafness
  • Fibrillary glomerulonephritis
  • Renal biopsy

ASJC Scopus subject areas

  • Nephrology

Cite this

Ichikawa, H., Ikeda, S., Hashimoto, M., Nagake, Y., Hironaka, K., Shikata, K., & Makino, H. (1997). Fibrillary glomerulonephritis in a patient with familial sensorineural deafness. Nephrology, 3(4), 381-384.

Fibrillary glomerulonephritis in a patient with familial sensorineural deafness. / Ichikawa, Haruo; Ikeda, Shuji; Hashimoto, Masami; Nagake, Yoshio; Hironaka, Kazue; Shikata, Kenichi; Makino, Hirofumi.

In: Nephrology, Vol. 3, No. 4, 1997, p. 381-384.

Research output: Contribution to journalArticle

Ichikawa, H, Ikeda, S, Hashimoto, M, Nagake, Y, Hironaka, K, Shikata, K & Makino, H 1997, 'Fibrillary glomerulonephritis in a patient with familial sensorineural deafness', Nephrology, vol. 3, no. 4, pp. 381-384.
Ichikawa H, Ikeda S, Hashimoto M, Nagake Y, Hironaka K, Shikata K et al. Fibrillary glomerulonephritis in a patient with familial sensorineural deafness. Nephrology. 1997;3(4):381-384.
Ichikawa, Haruo ; Ikeda, Shuji ; Hashimoto, Masami ; Nagake, Yoshio ; Hironaka, Kazue ; Shikata, Kenichi ; Makino, Hirofumi. / Fibrillary glomerulonephritis in a patient with familial sensorineural deafness. In: Nephrology. 1997 ; Vol. 3, No. 4. pp. 381-384.
@article{b805aa12dd904257b03bfeca8f6c39a2,
title = "Fibrillary glomerulonephritis in a patient with familial sensorineural deafness",
abstract = "A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.",
keywords = "Electron microscopy, Familial sensorineural deafness, Fibrillary glomerulonephritis, Renal biopsy",
author = "Haruo Ichikawa and Shuji Ikeda and Masami Hashimoto and Yoshio Nagake and Kazue Hironaka and Kenichi Shikata and Hirofumi Makino",
year = "1997",
language = "English",
volume = "3",
pages = "381--384",
journal = "Nephrology",
issn = "1320-5358",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Fibrillary glomerulonephritis in a patient with familial sensorineural deafness

AU - Ichikawa, Haruo

AU - Ikeda, Shuji

AU - Hashimoto, Masami

AU - Nagake, Yoshio

AU - Hironaka, Kazue

AU - Shikata, Kenichi

AU - Makino, Hirofumi

PY - 1997

Y1 - 1997

N2 - A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.

AB - A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.

KW - Electron microscopy

KW - Familial sensorineural deafness

KW - Fibrillary glomerulonephritis

KW - Renal biopsy

UR - http://www.scopus.com/inward/record.url?scp=0030825168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030825168&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 381

EP - 384

JO - Nephrology

JF - Nephrology

SN - 1320-5358

IS - 4

ER -