Abstract
A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.
| Original language | English |
|---|---|
| Pages (from-to) | 381-384 |
| Number of pages | 4 |
| Journal | Nephrology |
| Volume | 3 |
| Issue number | 4 |
| Publication status | Published - 1997 |
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Keywords
- Electron microscopy
- Familial sensorineural deafness
- Fibrillary glomerulonephritis
- Renal biopsy
ASJC Scopus subject areas
- Nephrology
Cite this
Fibrillary glomerulonephritis in a patient with familial sensorineural deafness. / Ichikawa, Haruo; Ikeda, Shuji; Hashimoto, Masami; Nagake, Yoshio; Hironaka, Kazue; Shikata, Kenichi; Makino, Hirofumi.
In: Nephrology, Vol. 3, No. 4, 1997, p. 381-384.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fibrillary glomerulonephritis in a patient with familial sensorineural deafness
AU - Ichikawa, Haruo
AU - Ikeda, Shuji
AU - Hashimoto, Masami
AU - Nagake, Yoshio
AU - Hironaka, Kazue
AU - Shikata, Kenichi
AU - Makino, Hirofumi
PY - 1997
Y1 - 1997
N2 - A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.
AB - A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.
KW - Electron microscopy
KW - Familial sensorineural deafness
KW - Fibrillary glomerulonephritis
KW - Renal biopsy
UR - http://www.scopus.com/inward/record.url?scp=0030825168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030825168&partnerID=8YFLogxK
M3 - Article
VL - 3
SP - 381
EP - 384
JO - Nephrology
JF - Nephrology
SN - 1320-5358
IS - 4
ER -