Fibrillary glomerulonephritis in a patient with familial sensorineural deafness

Haruo Ichikawa; Shuji Ikeda; Masami Hashimoto; Yoshio Nagake; Kazue Hironaka; Kenichi Shikata; Hirofumi Makino

doi:10.1111/j.1440-1797.1997.tb00259.x

Fibrillary glomerulonephritis in a patient with familial sensorineural deafness

Haruo Ichikawa, Shuji Ikeda, Masami Hashimoto, Yoshio Nagake, Kazue Hironaka, Kenichi Shikata, Hirofumi Makino

Research output: Contribution to journal › Article › peer-review

Abstract

A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.

Original language	English
Pages (from-to)	381-384
Number of pages	4
Journal	Nephrology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1111/j.1440-1797.1997.tb00259.x
Publication status	Published - Jan 1 1997

Keywords

Electron microscopy
Familial sensorineural deafness
Fibrillary glomerulonephritis
Renal biopsy

ASJC Scopus subject areas

Nephrology

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10.1111/j.1440-1797.1997.tb00259.x

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title = "Fibrillary glomerulonephritis in a patient with familial sensorineural deafness",

abstract = "A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.",

keywords = "Electron microscopy, Familial sensorineural deafness, Fibrillary glomerulonephritis, Renal biopsy",

author = "Haruo Ichikawa and Shuji Ikeda and Masami Hashimoto and Yoshio Nagake and Kazue Hironaka and Kenichi Shikata and Hirofumi Makino",

year = "1997",

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AU - Ichikawa, Haruo

AU - Ikeda, Shuji

AU - Hashimoto, Masami

AU - Nagake, Yoshio

AU - Hironaka, Kazue

AU - Shikata, Kenichi

AU - Makino, Hirofumi

PY - 1997/1/1

Y1 - 1997/1/1

N2 - A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.

AB - A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.

KW - Electron microscopy

KW - Familial sensorineural deafness

KW - Fibrillary glomerulonephritis

KW - Renal biopsy

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JO - Nephrology

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IS - 5

ER -

Fibrillary glomerulonephritis in a patient with familial sensorineural deafness

Abstract

Keywords

ASJC Scopus subject areas

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