Fibrillary glomerulonephritis in a patient with familial sensorineural deafness

Haruo Ichikawa, Shuji Ikeda, Masami Hashimoto, Yoshio Nagake, Kazue Hironaka, Kenichi Shikata, Hirofumi Makino

Research output: Contribution to journalArticle

Abstract

A 47-year-old woman was admitted to the hospital for evaluation of proteinuria. Bilateral sensorineural deafness had been diagnosed previously at age 35. She had a positive family history of deafness going back three generations. A renal biopsy showed the presence of highly organized fibrillary deposits in the subendothelial mesangial areas. The microfibrils had a diameter of 11-16 nm, larger than the diameter of amyloid fibrils, and did not have a microtubular appearance. The renal specimen was negative for Congo-red staining. There was no clinical or serologic evidence of paraproteinaemia, cryoglobulinaemia, light-chain disease, or systemic lupus erythematosus. The diagnosis was fibrillary glomerulonephritis. This is the first known case of fibrillary glomerulonephritis in a patient with familial sensorineural deafness.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalNephrology
Volume3
Issue number5
DOIs
Publication statusPublished - Jan 1 1997

Keywords

  • Electron microscopy
  • Familial sensorineural deafness
  • Fibrillary glomerulonephritis
  • Renal biopsy

ASJC Scopus subject areas

  • Nephrology

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