FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development

Hideyo Ohuchi, Yukiko Hori, Masahiro Yamasaki, Hidemitsu Harada, Keisuke Sekine, Shigeaki Kato, Nobuyuki Itoh

Research output: Contribution to journalArticle

452 Citations (Scopus)

Abstract

FGF receptor 2 isoform IIIb (FGFR2b), originally discovered as a receptor for FGF7, is known to be an important receptor in vertebrate morphogenesis, because FGFR2b null mice exhibit agenesis or dysgenesis of various organs, which undergo budding and branching morphogenesis. Since FGF7 null mice do not exhibit marked defects in organogenesis, it has been considered that other FGF(s) than FGF7 might function as a major ligand for FGFR2b during organogenesis. One of the candidate ligands is FGF10, because FGF10 binds to FGFR2b with high affinity and the formation of the limb and lung is arrested in FGF10 null mice as found in FGFR2b-deficient mice. Previous analyses of FGF10 null mice revealed that FGF10 is required for limb and lung development. To elucidate the role of FGF10 in wide-range organogenesis, we further analyzed the phenotypes of the FGF10 knockout mice. We found diverse phenotypes closely related to those for FGFR2b-deficient mice, which includes the absence of thyroid, pituitary, and salivary glands, while minor defects were observed in the formarion of teeth, kidneys, hair follicles, and digestive organs. These results suggest that FGF10 acts as a major ligand for FGFR2b in mouse multi-organ development. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)643-649
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume277
Issue number3
DOIs
Publication statusPublished - Nov 2 2000
Externally publishedYes

Keywords

  • Budding morphogenesis
  • Epithelial-mesenchymal interactions
  • FGF10
  • FGFR2b
  • Fibroblast growth factor 10
  • Knockout mouse
  • Organogenesis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development'. Together they form a unique fingerprint.

  • Cite this