FGF-10 is a growth factor for preadipocytes in white adipose tissue

Masahiro Yamasaki, Hisayo Emoto, Morichika Konishi, Tadahisa Mikami, Hideyo Ohuchi, Kazuwa Nakao, Nobuyuki Itoh

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

FGF-10 is a mesenchymal factor affecting epithelial cells during pattern formation. However, the expression and physiological role of FGF-10 in adults remains to be elucidated. We examined the expression of FGF-10 mRNA in a variety of adult rat tissues, and found to be most abundant in white adipose tissue. In white adipose tissue, FGF-10 mRNA was expressed in preadipocytes but not in mature adipocytes. The expression in white adipose tissue during postnatal development was also examined. The expression level was low at postnatal day 10 (P10). However, FGF-10 mRNA was abundantly detected later on (P28 and P48) when white adipose tissue growth was stimulated. We also examined the activity of recombinant FGF-10 for primary rat preadipocytes. FGF-10 showed significant mitogenic activity for primary preadipocytes, but did not affect the differentiation of preadipocytes. The expression profile of FGF-10 mRNA and the activity of FGF-10 reported here indicate that FGF-10, a unique secreted factor produced in white adipose tissue, acts as a growth factor for preadipocytes in white adipose tissues.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume258
Issue number1
DOIs
Publication statusPublished - Apr 29 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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