Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy

Nobuhiro Suzumori, Akihiko Sekizawa, Takeshi Ebara, Osamu Samura, Aiko Sasaki, Rina Akaishi, Seiji Wada, Haruka Hamanoue, Fumiki Hirahara, Haruna Izumi, Hideaki Sawai, Hiroaki Nakamura, Takahiro Yamada, Kiyonori Miura, Hideaki Masuzaki, Takahiro Yamashita, Takashi Okai, Yoshimasa Kamei, Akira Namba, Jun MurotsukiTomohiro Tanemoto, Akimune Fukushima, Kazufumi Haino, Shinya Tairaku, Keiichi Matsubara, Kazutoshi Maeda, Takashi Kaji, Masanobu Ogawa, Hisao Osada, Haruki Nishizawa, Yoko Okamoto, Takeshi Kanagawa, Aiko Kakigano, Michihiro Kitagawa, Masaki Ogawa, Shunichiro Izumi, Yukiko Katagiri, Naoki Takeshita, Yasuyo Kasai, Katsuhiko Naruse, Reiko Neki, Hisashi Masuyama, Maki Hyodo, Yukie Kawano, Takashi Ohba, Kiyotake Ichizuka, Takeshi Nagamatsu, Atsushi Watanabe, Nahoko Shirato, Junko Yotsumoto, Miyuki Nishiyama, Tatsuko Hirose, Haruhiko Sago

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The purpose of this study is to compare the fetal fractions during non-invasive prenatal testing (NIPT) in singleton pregnancies according to gestational age and maternal characteristics to evaluate the utility of this parameter for the prediction of pregnancy complications including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). Study design: This study was a multicenter prospective cohort study. The present data were collected from women whose NIPT results were negative. The relationships between the fetal fractions and the gestational age, maternal weight and height, and incidences of miscarriage, preterm delivery, and pregnancy complications including GDM, HDP and placental abruption were assessed. Results: A total of 5582 pregnant women with verified NIPT negative results were registered in the study. The demographic characteristics of the study populations were statistically analyzed, and the women with HDP tended to have a low fetal fraction in samples taken during early gestation. The area under the curve (AUC) in a receiver operating characteristic curve (ROC) analysis was 0.608 for women with HDP. Conclusion: A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume224
DOIs
Publication statusPublished - May 1 2018

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Keywords

  • Cell-free DNA
  • Fetal fraction
  • HDP
  • NIPT
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Suzumori, N., Sekizawa, A., Ebara, T., Samura, O., Sasaki, A., Akaishi, R., Wada, S., Hamanoue, H., Hirahara, F., Izumi, H., Sawai, H., Nakamura, H., Yamada, T., Miura, K., Masuzaki, H., Yamashita, T., Okai, T., Kamei, Y., Namba, A., ... Sago, H. (2018). Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy. European Journal of Obstetrics Gynecology and Reproductive Biology, 224, 165-169. https://doi.org/10.1016/j.ejogrb.2018.03.048