Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy

Nobuhiro Suzumori, Akihiko Sekizawa, Takeshi Ebara, Osamu Samura, Aiko Sasaki, Rina Akaishi, Seiji Wada, Haruka Hamanoue, Fumiki Hirahara, Haruna Izumi, Hideaki Sawai, Hiroaki Nakamura, Takahiro Yamada, Kiyonori Miura, Hideaki Masuzaki, Takahiro Yamashita, Takashi Okai, Yoshimasa Kamei, Akira Namba, Jun MurotsukiTomohiro Tanemoto, Akimune Fukushima, Kazufumi Haino, Shinya Tairaku, Keiichi Matsubara, Kazutoshi Maeda, Takashi Kaji, Masanobu Ogawa, Hisao Osada, Haruki Nishizawa, Yoko Okamoto, Takeshi Kanagawa, Aiko Kakigano, Michihiro Kitagawa, Masaki Ogawa, Shunichiro Izumi, Yukiko Katagiri, Naoki Takeshita, Yasuyo Kasai, Katsuhiko Naruse, Reiko Neki, Hisashi Masuyama, Maki Hyodo, Yukie Kawano, Takashi Ohba, Kiyotake Ichizuka, Takeshi Nagamatsu, Atsushi Watanabe, Nahoko Shirato, Junko Yotsumoto, Miyuki Nishiyama, Tatsuko Hirose, Haruhiko Sago

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: The purpose of this study is to compare the fetal fractions during non-invasive prenatal testing (NIPT) in singleton pregnancies according to gestational age and maternal characteristics to evaluate the utility of this parameter for the prediction of pregnancy complications including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). Study design: This study was a multicenter prospective cohort study. The present data were collected from women whose NIPT results were negative. The relationships between the fetal fractions and the gestational age, maternal weight and height, and incidences of miscarriage, preterm delivery, and pregnancy complications including GDM, HDP and placental abruption were assessed. Results: A total of 5582 pregnant women with verified NIPT negative results were registered in the study. The demographic characteristics of the study populations were statistically analyzed, and the women with HDP tended to have a low fetal fraction in samples taken during early gestation. The area under the curve (AUC) in a receiver operating characteristic curve (ROC) analysis was 0.608 for women with HDP. Conclusion: A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume224
DOIs
Publication statusPublished - May 1 2018

Fingerprint

Mothers
Pregnancy
DNA
Surrogate Mothers
Gestational Diabetes
Pregnancy Complications
Gestational Age
Abruptio Placentae
Spontaneous Abortion
Population Characteristics
ROC Curve
Area Under Curve
Pregnant Women
Cohort Studies
Demography
Prospective Studies
Weights and Measures
Incidence

Keywords

  • Cell-free DNA
  • Fetal fraction
  • HDP
  • NIPT
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy. / Suzumori, Nobuhiro; Sekizawa, Akihiko; Ebara, Takeshi; Samura, Osamu; Sasaki, Aiko; Akaishi, Rina; Wada, Seiji; Hamanoue, Haruka; Hirahara, Fumiki; Izumi, Haruna; Sawai, Hideaki; Nakamura, Hiroaki; Yamada, Takahiro; Miura, Kiyonori; Masuzaki, Hideaki; Yamashita, Takahiro; Okai, Takashi; Kamei, Yoshimasa; Namba, Akira; Murotsuki, Jun; Tanemoto, Tomohiro; Fukushima, Akimune; Haino, Kazufumi; Tairaku, Shinya; Matsubara, Keiichi; Maeda, Kazutoshi; Kaji, Takashi; Ogawa, Masanobu; Osada, Hisao; Nishizawa, Haruki; Okamoto, Yoko; Kanagawa, Takeshi; Kakigano, Aiko; Kitagawa, Michihiro; Ogawa, Masaki; Izumi, Shunichiro; Katagiri, Yukiko; Takeshita, Naoki; Kasai, Yasuyo; Naruse, Katsuhiko; Neki, Reiko; Masuyama, Hisashi; Hyodo, Maki; Kawano, Yukie; Ohba, Takashi; Ichizuka, Kiyotake; Nagamatsu, Takeshi; Watanabe, Atsushi; Shirato, Nahoko; Yotsumoto, Junko; Nishiyama, Miyuki; Hirose, Tatsuko; Sago, Haruhiko.

In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 224, 01.05.2018, p. 165-169.

Research output: Contribution to journalArticle

Suzumori, N, Sekizawa, A, Ebara, T, Samura, O, Sasaki, A, Akaishi, R, Wada, S, Hamanoue, H, Hirahara, F, Izumi, H, Sawai, H, Nakamura, H, Yamada, T, Miura, K, Masuzaki, H, Yamashita, T, Okai, T, Kamei, Y, Namba, A, Murotsuki, J, Tanemoto, T, Fukushima, A, Haino, K, Tairaku, S, Matsubara, K, Maeda, K, Kaji, T, Ogawa, M, Osada, H, Nishizawa, H, Okamoto, Y, Kanagawa, T, Kakigano, A, Kitagawa, M, Ogawa, M, Izumi, S, Katagiri, Y, Takeshita, N, Kasai, Y, Naruse, K, Neki, R, Masuyama, H, Hyodo, M, Kawano, Y, Ohba, T, Ichizuka, K, Nagamatsu, T, Watanabe, A, Shirato, N, Yotsumoto, J, Nishiyama, M, Hirose, T & Sago, H 2018, 'Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy', European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 224, pp. 165-169. https://doi.org/10.1016/j.ejogrb.2018.03.048
Suzumori, Nobuhiro ; Sekizawa, Akihiko ; Ebara, Takeshi ; Samura, Osamu ; Sasaki, Aiko ; Akaishi, Rina ; Wada, Seiji ; Hamanoue, Haruka ; Hirahara, Fumiki ; Izumi, Haruna ; Sawai, Hideaki ; Nakamura, Hiroaki ; Yamada, Takahiro ; Miura, Kiyonori ; Masuzaki, Hideaki ; Yamashita, Takahiro ; Okai, Takashi ; Kamei, Yoshimasa ; Namba, Akira ; Murotsuki, Jun ; Tanemoto, Tomohiro ; Fukushima, Akimune ; Haino, Kazufumi ; Tairaku, Shinya ; Matsubara, Keiichi ; Maeda, Kazutoshi ; Kaji, Takashi ; Ogawa, Masanobu ; Osada, Hisao ; Nishizawa, Haruki ; Okamoto, Yoko ; Kanagawa, Takeshi ; Kakigano, Aiko ; Kitagawa, Michihiro ; Ogawa, Masaki ; Izumi, Shunichiro ; Katagiri, Yukiko ; Takeshita, Naoki ; Kasai, Yasuyo ; Naruse, Katsuhiko ; Neki, Reiko ; Masuyama, Hisashi ; Hyodo, Maki ; Kawano, Yukie ; Ohba, Takashi ; Ichizuka, Kiyotake ; Nagamatsu, Takeshi ; Watanabe, Atsushi ; Shirato, Nahoko ; Yotsumoto, Junko ; Nishiyama, Miyuki ; Hirose, Tatsuko ; Sago, Haruhiko. / Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy. In: European Journal of Obstetrics Gynecology and Reproductive Biology. 2018 ; Vol. 224. pp. 165-169.
@article{1250b51b1a02475896c5b356fbb51cd7,
title = "Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy",
abstract = "Objective: The purpose of this study is to compare the fetal fractions during non-invasive prenatal testing (NIPT) in singleton pregnancies according to gestational age and maternal characteristics to evaluate the utility of this parameter for the prediction of pregnancy complications including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). Study design: This study was a multicenter prospective cohort study. The present data were collected from women whose NIPT results were negative. The relationships between the fetal fractions and the gestational age, maternal weight and height, and incidences of miscarriage, preterm delivery, and pregnancy complications including GDM, HDP and placental abruption were assessed. Results: A total of 5582 pregnant women with verified NIPT negative results were registered in the study. The demographic characteristics of the study populations were statistically analyzed, and the women with HDP tended to have a low fetal fraction in samples taken during early gestation. The area under the curve (AUC) in a receiver operating characteristic curve (ROC) analysis was 0.608 for women with HDP. Conclusion: A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult.",
keywords = "Cell-free DNA, Fetal fraction, HDP, NIPT, Prenatal diagnosis",
author = "Nobuhiro Suzumori and Akihiko Sekizawa and Takeshi Ebara and Osamu Samura and Aiko Sasaki and Rina Akaishi and Seiji Wada and Haruka Hamanoue and Fumiki Hirahara and Haruna Izumi and Hideaki Sawai and Hiroaki Nakamura and Takahiro Yamada and Kiyonori Miura and Hideaki Masuzaki and Takahiro Yamashita and Takashi Okai and Yoshimasa Kamei and Akira Namba and Jun Murotsuki and Tomohiro Tanemoto and Akimune Fukushima and Kazufumi Haino and Shinya Tairaku and Keiichi Matsubara and Kazutoshi Maeda and Takashi Kaji and Masanobu Ogawa and Hisao Osada and Haruki Nishizawa and Yoko Okamoto and Takeshi Kanagawa and Aiko Kakigano and Michihiro Kitagawa and Masaki Ogawa and Shunichiro Izumi and Yukiko Katagiri and Naoki Takeshita and Yasuyo Kasai and Katsuhiko Naruse and Reiko Neki and Hisashi Masuyama and Maki Hyodo and Yukie Kawano and Takashi Ohba and Kiyotake Ichizuka and Takeshi Nagamatsu and Atsushi Watanabe and Nahoko Shirato and Junko Yotsumoto and Miyuki Nishiyama and Tatsuko Hirose and Haruhiko Sago",
year = "2018",
month = "5",
day = "1",
doi = "10.1016/j.ejogrb.2018.03.048",
language = "English",
volume = "224",
pages = "165--169",
journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",
issn = "0028-2243",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy

AU - Suzumori, Nobuhiro

AU - Sekizawa, Akihiko

AU - Ebara, Takeshi

AU - Samura, Osamu

AU - Sasaki, Aiko

AU - Akaishi, Rina

AU - Wada, Seiji

AU - Hamanoue, Haruka

AU - Hirahara, Fumiki

AU - Izumi, Haruna

AU - Sawai, Hideaki

AU - Nakamura, Hiroaki

AU - Yamada, Takahiro

AU - Miura, Kiyonori

AU - Masuzaki, Hideaki

AU - Yamashita, Takahiro

AU - Okai, Takashi

AU - Kamei, Yoshimasa

AU - Namba, Akira

AU - Murotsuki, Jun

AU - Tanemoto, Tomohiro

AU - Fukushima, Akimune

AU - Haino, Kazufumi

AU - Tairaku, Shinya

AU - Matsubara, Keiichi

AU - Maeda, Kazutoshi

AU - Kaji, Takashi

AU - Ogawa, Masanobu

AU - Osada, Hisao

AU - Nishizawa, Haruki

AU - Okamoto, Yoko

AU - Kanagawa, Takeshi

AU - Kakigano, Aiko

AU - Kitagawa, Michihiro

AU - Ogawa, Masaki

AU - Izumi, Shunichiro

AU - Katagiri, Yukiko

AU - Takeshita, Naoki

AU - Kasai, Yasuyo

AU - Naruse, Katsuhiko

AU - Neki, Reiko

AU - Masuyama, Hisashi

AU - Hyodo, Maki

AU - Kawano, Yukie

AU - Ohba, Takashi

AU - Ichizuka, Kiyotake

AU - Nagamatsu, Takeshi

AU - Watanabe, Atsushi

AU - Shirato, Nahoko

AU - Yotsumoto, Junko

AU - Nishiyama, Miyuki

AU - Hirose, Tatsuko

AU - Sago, Haruhiko

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Objective: The purpose of this study is to compare the fetal fractions during non-invasive prenatal testing (NIPT) in singleton pregnancies according to gestational age and maternal characteristics to evaluate the utility of this parameter for the prediction of pregnancy complications including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). Study design: This study was a multicenter prospective cohort study. The present data were collected from women whose NIPT results were negative. The relationships between the fetal fractions and the gestational age, maternal weight and height, and incidences of miscarriage, preterm delivery, and pregnancy complications including GDM, HDP and placental abruption were assessed. Results: A total of 5582 pregnant women with verified NIPT negative results were registered in the study. The demographic characteristics of the study populations were statistically analyzed, and the women with HDP tended to have a low fetal fraction in samples taken during early gestation. The area under the curve (AUC) in a receiver operating characteristic curve (ROC) analysis was 0.608 for women with HDP. Conclusion: A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult.

AB - Objective: The purpose of this study is to compare the fetal fractions during non-invasive prenatal testing (NIPT) in singleton pregnancies according to gestational age and maternal characteristics to evaluate the utility of this parameter for the prediction of pregnancy complications including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). Study design: This study was a multicenter prospective cohort study. The present data were collected from women whose NIPT results were negative. The relationships between the fetal fractions and the gestational age, maternal weight and height, and incidences of miscarriage, preterm delivery, and pregnancy complications including GDM, HDP and placental abruption were assessed. Results: A total of 5582 pregnant women with verified NIPT negative results were registered in the study. The demographic characteristics of the study populations were statistically analyzed, and the women with HDP tended to have a low fetal fraction in samples taken during early gestation. The area under the curve (AUC) in a receiver operating characteristic curve (ROC) analysis was 0.608 for women with HDP. Conclusion: A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult.

KW - Cell-free DNA

KW - Fetal fraction

KW - HDP

KW - NIPT

KW - Prenatal diagnosis

UR - http://www.scopus.com/inward/record.url?scp=85044607263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044607263&partnerID=8YFLogxK

U2 - 10.1016/j.ejogrb.2018.03.048

DO - 10.1016/j.ejogrb.2018.03.048

M3 - Article

C2 - 29605711

AN - SCOPUS:85044607263

VL - 224

SP - 165

EP - 169

JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

JF - European Journal of Obstetrics and Gynecology and Reproductive Biology

SN - 0028-2243

ER -