Abstract
Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan. Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Results from the survivors of other than gynecological disease who underwent chemotherapy were analyzed. Results: Among the survivors, 41.4% were concerned about their reproductive function and infertility, and 36.2% were aware of menstrual cycle abnormalities. Among them, 15.5% (n = 20) of all and 21.2% (n = 17) of the AYA-onset survivors suffered infertility due to chemo- or radiotherapy and gave up childbearing. These rates were significantly higher than those of healthy AYAs. Although 80.8% of AYA-onset survivors answered that they had received information on reproductive function and infertility, only 55.8% had received information on fertility preservation methods. Furthermore, only 22.4% of all and 42.3% of AYA-onset survivors had received pretreatment information on fertility preservation methods. Conclusions: Not a few AYA cancer survivors reported reproductive dysfunction. These findings indicate that information provided on therapy-related problems before cancer treatment in Japan was insufficient and highlight the need to improve patient decision-making and support systems for fertility preservation.
| Original language | English |
|---|---|
| Journal | Reproductive Medicine and Biology |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2018 |
Fingerprint
Keywords
- adolescent
- cancer survivors
- fertility preservation
- reproduction
- young adults
ASJC Scopus subject areas
- Reproductive Medicine
- Cell Biology
Cite this
Fertility preservation in adolescent and young adult cancer patients : From a part of a national survey on oncofertility in Japan. / Furui, Tatsuro; Takai, Yasushi; Kimura, Fuminori; Kitajima, Michio; Nakatsuka, Mikiya; Morishige, Ken ichiro; Higuchi, Akiko; Shimizu, Chikako; Ozawa, Miwa; Ohara, Akira; Tatara, Ryohei; Nakamura, Terukazu; Horibe, Keizo; Suzuki, Nao.
In: Reproductive Medicine and Biology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fertility preservation in adolescent and young adult cancer patients
T2 - From a part of a national survey on oncofertility in Japan
AU - Furui, Tatsuro
AU - Takai, Yasushi
AU - Kimura, Fuminori
AU - Kitajima, Michio
AU - Nakatsuka, Mikiya
AU - Morishige, Ken ichiro
AU - Higuchi, Akiko
AU - Shimizu, Chikako
AU - Ozawa, Miwa
AU - Ohara, Akira
AU - Tatara, Ryohei
AU - Nakamura, Terukazu
AU - Horibe, Keizo
AU - Suzuki, Nao
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan. Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Results from the survivors of other than gynecological disease who underwent chemotherapy were analyzed. Results: Among the survivors, 41.4% were concerned about their reproductive function and infertility, and 36.2% were aware of menstrual cycle abnormalities. Among them, 15.5% (n = 20) of all and 21.2% (n = 17) of the AYA-onset survivors suffered infertility due to chemo- or radiotherapy and gave up childbearing. These rates were significantly higher than those of healthy AYAs. Although 80.8% of AYA-onset survivors answered that they had received information on reproductive function and infertility, only 55.8% had received information on fertility preservation methods. Furthermore, only 22.4% of all and 42.3% of AYA-onset survivors had received pretreatment information on fertility preservation methods. Conclusions: Not a few AYA cancer survivors reported reproductive dysfunction. These findings indicate that information provided on therapy-related problems before cancer treatment in Japan was insufficient and highlight the need to improve patient decision-making and support systems for fertility preservation.
AB - Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan. Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Results from the survivors of other than gynecological disease who underwent chemotherapy were analyzed. Results: Among the survivors, 41.4% were concerned about their reproductive function and infertility, and 36.2% were aware of menstrual cycle abnormalities. Among them, 15.5% (n = 20) of all and 21.2% (n = 17) of the AYA-onset survivors suffered infertility due to chemo- or radiotherapy and gave up childbearing. These rates were significantly higher than those of healthy AYAs. Although 80.8% of AYA-onset survivors answered that they had received information on reproductive function and infertility, only 55.8% had received information on fertility preservation methods. Furthermore, only 22.4% of all and 42.3% of AYA-onset survivors had received pretreatment information on fertility preservation methods. Conclusions: Not a few AYA cancer survivors reported reproductive dysfunction. These findings indicate that information provided on therapy-related problems before cancer treatment in Japan was insufficient and highlight the need to improve patient decision-making and support systems for fertility preservation.
KW - adolescent
KW - cancer survivors
KW - fertility preservation
KW - reproduction
KW - young adults
UR - http://www.scopus.com/inward/record.url?scp=85056795470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056795470&partnerID=8YFLogxK
U2 - 10.1002/rmb2.12256
DO - 10.1002/rmb2.12256
M3 - Article
AN - SCOPUS:85056795470
JO - Reproductive Medicine and Biology
JF - Reproductive Medicine and Biology
SN - 1445-5781
ER -