Fertility preservation in adolescent and young adult cancer patients: From a part of a national survey on oncofertility in Japan

Tatsuro Furui, Yasushi Takai, Fuminori Kimura, Michio Kitajima, Mikiya Nakatsuka, Ken ichiro Morishige, Akiko Higuchi, Chikako Shimizu, Miwa Ozawa, Akira Ohara, Ryohei Tatara, Terukazu Nakamura, Keizo Horibe, Nao Suzuki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan. Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Results from the survivors of other than gynecological disease who underwent chemotherapy were analyzed. Results: Among the survivors, 41.4% were concerned about their reproductive function and infertility, and 36.2% were aware of menstrual cycle abnormalities. Among them, 15.5% (n = 20) of all and 21.2% (n = 17) of the AYA-onset survivors suffered infertility due to chemo- or radiotherapy and gave up childbearing. These rates were significantly higher than those of healthy AYAs. Although 80.8% of AYA-onset survivors answered that they had received information on reproductive function and infertility, only 55.8% had received information on fertility preservation methods. Furthermore, only 22.4% of all and 42.3% of AYA-onset survivors had received pretreatment information on fertility preservation methods. Conclusions: Not a few AYA cancer survivors reported reproductive dysfunction. These findings indicate that information provided on therapy-related problems before cancer treatment in Japan was insufficient and highlight the need to improve patient decision-making and support systems for fertility preservation.

Original languageEnglish
JournalReproductive Medicine and Biology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Fertility Preservation
Survivors
Young Adult
Japan
Neoplasms
Infertility
Drug Therapy
Menstrual Cycle
Surveys and Questionnaires
Decision Making
Radiotherapy
Therapeutics

Keywords

  • adolescent
  • cancer survivors
  • fertility preservation
  • reproduction
  • young adults

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

Cite this

Fertility preservation in adolescent and young adult cancer patients : From a part of a national survey on oncofertility in Japan. / Furui, Tatsuro; Takai, Yasushi; Kimura, Fuminori; Kitajima, Michio; Nakatsuka, Mikiya; Morishige, Ken ichiro; Higuchi, Akiko; Shimizu, Chikako; Ozawa, Miwa; Ohara, Akira; Tatara, Ryohei; Nakamura, Terukazu; Horibe, Keizo; Suzuki, Nao.

In: Reproductive Medicine and Biology, 01.01.2018.

Research output: Contribution to journalArticle

Furui, T, Takai, Y, Kimura, F, Kitajima, M, Nakatsuka, M, Morishige, KI, Higuchi, A, Shimizu, C, Ozawa, M, Ohara, A, Tatara, R, Nakamura, T, Horibe, K & Suzuki, N 2018, 'Fertility preservation in adolescent and young adult cancer patients: From a part of a national survey on oncofertility in Japan', Reproductive Medicine and Biology. https://doi.org/10.1002/rmb2.12256
Furui, Tatsuro ; Takai, Yasushi ; Kimura, Fuminori ; Kitajima, Michio ; Nakatsuka, Mikiya ; Morishige, Ken ichiro ; Higuchi, Akiko ; Shimizu, Chikako ; Ozawa, Miwa ; Ohara, Akira ; Tatara, Ryohei ; Nakamura, Terukazu ; Horibe, Keizo ; Suzuki, Nao. / Fertility preservation in adolescent and young adult cancer patients : From a part of a national survey on oncofertility in Japan. In: Reproductive Medicine and Biology. 2018.
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AU - Furui, Tatsuro

AU - Takai, Yasushi

AU - Kimura, Fuminori

AU - Kitajima, Michio

AU - Nakatsuka, Mikiya

AU - Morishige, Ken ichiro

AU - Higuchi, Akiko

AU - Shimizu, Chikako

AU - Ozawa, Miwa

AU - Ohara, Akira

AU - Tatara, Ryohei

AU - Nakamura, Terukazu

AU - Horibe, Keizo

AU - Suzuki, Nao

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N2 - Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan. Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Results from the survivors of other than gynecological disease who underwent chemotherapy were analyzed. Results: Among the survivors, 41.4% were concerned about their reproductive function and infertility, and 36.2% were aware of menstrual cycle abnormalities. Among them, 15.5% (n = 20) of all and 21.2% (n = 17) of the AYA-onset survivors suffered infertility due to chemo- or radiotherapy and gave up childbearing. These rates were significantly higher than those of healthy AYAs. Although 80.8% of AYA-onset survivors answered that they had received information on reproductive function and infertility, only 55.8% had received information on fertility preservation methods. Furthermore, only 22.4% of all and 42.3% of AYA-onset survivors had received pretreatment information on fertility preservation methods. Conclusions: Not a few AYA cancer survivors reported reproductive dysfunction. These findings indicate that information provided on therapy-related problems before cancer treatment in Japan was insufficient and highlight the need to improve patient decision-making and support systems for fertility preservation.

AB - Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan. Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Results from the survivors of other than gynecological disease who underwent chemotherapy were analyzed. Results: Among the survivors, 41.4% were concerned about their reproductive function and infertility, and 36.2% were aware of menstrual cycle abnormalities. Among them, 15.5% (n = 20) of all and 21.2% (n = 17) of the AYA-onset survivors suffered infertility due to chemo- or radiotherapy and gave up childbearing. These rates were significantly higher than those of healthy AYAs. Although 80.8% of AYA-onset survivors answered that they had received information on reproductive function and infertility, only 55.8% had received information on fertility preservation methods. Furthermore, only 22.4% of all and 42.3% of AYA-onset survivors had received pretreatment information on fertility preservation methods. Conclusions: Not a few AYA cancer survivors reported reproductive dysfunction. These findings indicate that information provided on therapy-related problems before cancer treatment in Japan was insufficient and highlight the need to improve patient decision-making and support systems for fertility preservation.

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