Fertility preservation in adolescent and young adult cancer patients: From a part of a national survey on oncofertility in Japan

Tatsuro Furui, Yasushi Takai, Fuminori Kimura, Michio Kitajima, Mikiya Nakatsuka, Ken ichiro Morishige, Akiko Higuchi, Chikako Shimizu, Miwa Ozawa, Akira Ohara, Ryohei Tatara, Terukazu Nakamura, Keizo Horibe, Nao Suzuki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan. Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Results from the survivors of other than gynecological disease who underwent chemotherapy were analyzed. Results: Among the survivors, 41.4% were concerned about their reproductive function and infertility, and 36.2% were aware of menstrual cycle abnormalities. Among them, 15.5% (n = 20) of all and 21.2% (n = 17) of the AYA-onset survivors suffered infertility due to chemo- or radiotherapy and gave up childbearing. These rates were significantly higher than those of healthy AYAs. Although 80.8% of AYA-onset survivors answered that they had received information on reproductive function and infertility, only 55.8% had received information on fertility preservation methods. Furthermore, only 22.4% of all and 42.3% of AYA-onset survivors had received pretreatment information on fertility preservation methods. Conclusions: Not a few AYA cancer survivors reported reproductive dysfunction. These findings indicate that information provided on therapy-related problems before cancer treatment in Japan was insufficient and highlight the need to improve patient decision-making and support systems for fertility preservation.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalReproductive Medicine and Biology
Issue number1
Publication statusPublished - Jan 2019


  • adolescent
  • cancer survivors
  • fertility preservation
  • reproduction
  • young adults

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology


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