Female dominant association of sarcopenia and physical frailty in mild cognitive impairment and Alzheimer's disease

Yasuyuki Ohta, Emi Nomura, Noriko Hatanaka, Yosuke Osakada, Namiko Matsumoto, Ryo Sasaki, Keiichiro Tsunoda, Mami Takemoto, Koh Tadokoro, Nozomi Hishikawa, Yosuke Wakutani, Toru Yamashita, Kota Sato, Yoshio Omote, Koji Abe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Associations of sarcopenia and physical frailty in cognitive and affective (depression, apathy, and behavioral and psychological symptoms of dementia) functions of mild cognitive impairment (MCI) and Alzheimer's disease (AD) were not fully evaluated previously, especially not for gender differences. 165 AD, 84 MCI, and 48 control participants (175 female, 122 male) were evaluated for cognitive, affective, activities of daily living (ADL), and physical functions associated with sarcopenia and physical frailty. In both sexes, cognitive and affective functions, ADL, and physical functions worsened in MCI and AD compared to control subjects. Physical dysfunctions, especially slow gait speed (3 m up and go test), were significantly associated with cognitive, affective, and ADL declines in participants (control subjects, MCI, and AD) of each gender, which were especially noticeable in females. The present study may be the first to suggest significant associations of sarcopenia and physical frailty with cognitive and affective functions of MCI and AD, especially in females.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalJournal of Clinical Neuroscience
Volume70
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Alzheimer's disease
  • Gender difference
  • MCI
  • Physical frailty
  • Sarcopenia

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Female dominant association of sarcopenia and physical frailty in mild cognitive impairment and Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this