Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs

Masaru Sugimachi, Kazunori Uemura, Atsunori Kamiya, Shuji Shimizu, Masashi Inagaki, Toshiaki Shishido

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The ultimate goal of disease treatment is to control the biological system beyond the native regulation to combat pathological process. To maximize the advantage of drugs, we attempted to pharmacologically control the biological system at will, e.g., control multiple hemodynamic variables with multiple cardiovascular drugs. A comprehensive physiological cardiovascular model enabled us to evaluate cardiovascular properties (pump function, vascular resistance, and blood volume) and the feedback control of these properties. In 12 dogs, with dobutamine (5±3 μg·kg-1·min-1), nitroprusside (4±2 μg·kg-1·min-1), dextran (2±2 ml·kg-1), and furosemide (10 mg in one, 20 mg in one), rapid, sufficient and stable control of pump function, vascular resistance and blood volume resulted in similarly quick and stable control of blood pressure, cardiac output and left atrial pressure in 5±7, 7±5, and 12±10 minutes, respectively. These variables remained stable for 60 minutes (RMS 4±3 mmHg, 5±2 ml·min -1·kg-1, 0.8±0.6 mmHg, respectively).

Original languageEnglish
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages2030-2032
Number of pages3
ISBN (Print)9781424432967
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Publication series

NameProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

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  • Cite this

    Sugimachi, M., Uemura, K., Kamiya, A., Shimizu, S., Inagaki, M., & Shishido, T. (2009). Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 2030-2032). [5334417] (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5334417