TY - GEN
T1 - Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs
AU - Sugimachi, Masaru
AU - Uemura, Kazunori
AU - Kamiya, Atsunori
AU - Shimizu, Shuji
AU - Inagaki, Masashi
AU - Shishido, Toshiaki
PY - 2009/1/1
Y1 - 2009/1/1
N2 - The ultimate goal of disease treatment is to control the biological system beyond the native regulation to combat pathological process. To maximize the advantage of drugs, we attempted to pharmacologically control the biological system at will, e.g., control multiple hemodynamic variables with multiple cardiovascular drugs. A comprehensive physiological cardiovascular model enabled us to evaluate cardiovascular properties (pump function, vascular resistance, and blood volume) and the feedback control of these properties. In 12 dogs, with dobutamine (5±3 μg·kg-1·min-1), nitroprusside (4±2 μg·kg-1·min-1), dextran (2±2 ml·kg-1), and furosemide (10 mg in one, 20 mg in one), rapid, sufficient and stable control of pump function, vascular resistance and blood volume resulted in similarly quick and stable control of blood pressure, cardiac output and left atrial pressure in 5±7, 7±5, and 12±10 minutes, respectively. These variables remained stable for 60 minutes (RMS 4±3 mmHg, 5±2 ml·min -1·kg-1, 0.8±0.6 mmHg, respectively).
AB - The ultimate goal of disease treatment is to control the biological system beyond the native regulation to combat pathological process. To maximize the advantage of drugs, we attempted to pharmacologically control the biological system at will, e.g., control multiple hemodynamic variables with multiple cardiovascular drugs. A comprehensive physiological cardiovascular model enabled us to evaluate cardiovascular properties (pump function, vascular resistance, and blood volume) and the feedback control of these properties. In 12 dogs, with dobutamine (5±3 μg·kg-1·min-1), nitroprusside (4±2 μg·kg-1·min-1), dextran (2±2 ml·kg-1), and furosemide (10 mg in one, 20 mg in one), rapid, sufficient and stable control of pump function, vascular resistance and blood volume resulted in similarly quick and stable control of blood pressure, cardiac output and left atrial pressure in 5±7, 7±5, and 12±10 minutes, respectively. These variables remained stable for 60 minutes (RMS 4±3 mmHg, 5±2 ml·min -1·kg-1, 0.8±0.6 mmHg, respectively).
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U2 - 10.1109/IEMBS.2009.5334417
DO - 10.1109/IEMBS.2009.5334417
M3 - Conference contribution
C2 - 19964770
AN - SCOPUS:77950964134
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 2030
EP - 2032
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -