Fecal immunochemical test and fecal calprotectin results show different profiles in disease monitoring for ulcerative colitis

Sakiko Hiraoka, Toshihiro Inokuchi, Asuka Nakarai, Shiho Takashima, Daisuke Takei, Yuusaku Sugihara, Masahiro Takahara, Keita Harada, Hiroyuki Okada, Jun Kato

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: Both fecal immunochemical test (FIT) and fecal calprotectin (Fcal) results are useful biomarkers for ulcerative colitis (UC). However, the situations in which each marker should be used are largely unknown. Methods: A total of 110 colonoscopy intervals of UC patients were assessed, and correlations between changes in colonoscopic findings and changes in the two aforementioned fecal markers were examined. Results: Among patients with mucosal healing (MH) and negative FIT or Fcal results at the initial colonoscopy, FIT and Fcal findings exhibited accuracies of 93% (38/41) and 79% (26/33), respectively, for predicting the results of the subsequent examination. Among the 24 patients who showed endoscopic activity at the precedent colonoscopy and MH at the subsequent examination, positive-to-negative conversion of FIT and Fcal findings at the subsequent examination was observed in 92% (12/13) and 62% (8/13) of patients, respectively. Among the 43 patients who showed endoscopic activity at both the precedent and subsequent examinations, Fcal findings reflected the change in endoscopic activity better than FIT results (r=0.59, p<0.0001 vs r=0.30, p=0.054). Conclusions: The FIT is useful for confirming MH and the occurrence of relapse. In contrast, Fcal is useful for monitoring the mucosal status of patients with active inflammation. (Gut Liver 2018;12:142-148).

Original languageEnglish
Pages (from-to)142-148
Number of pages7
JournalGut and Liver
Volume12
Issue number2
DOIs
Publication statusPublished - Mar 1 2018

Fingerprint

Leukocyte L1 Antigen Complex
Ulcerative Colitis
Colonoscopy
Biomarkers
Inflammation
Recurrence
Liver

Keywords

  • Colitis
  • Fecal calprotectin
  • Quantitative fecal immunochemical test
  • Ulcerative

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Fecal immunochemical test and fecal calprotectin results show different profiles in disease monitoring for ulcerative colitis. / Hiraoka, Sakiko; Inokuchi, Toshihiro; Nakarai, Asuka; Takashima, Shiho; Takei, Daisuke; Sugihara, Yuusaku; Takahara, Masahiro; Harada, Keita; Okada, Hiroyuki; Kato, Jun.

In: Gut and Liver, Vol. 12, No. 2, 01.03.2018, p. 142-148.

Research output: Contribution to journalArticle

Hiraoka, Sakiko ; Inokuchi, Toshihiro ; Nakarai, Asuka ; Takashima, Shiho ; Takei, Daisuke ; Sugihara, Yuusaku ; Takahara, Masahiro ; Harada, Keita ; Okada, Hiroyuki ; Kato, Jun. / Fecal immunochemical test and fecal calprotectin results show different profiles in disease monitoring for ulcerative colitis. In: Gut and Liver. 2018 ; Vol. 12, No. 2. pp. 142-148.
@article{95bcbc4d9a294690898335ba8ffcfa77,
title = "Fecal immunochemical test and fecal calprotectin results show different profiles in disease monitoring for ulcerative colitis",
abstract = "Background/Aims: Both fecal immunochemical test (FIT) and fecal calprotectin (Fcal) results are useful biomarkers for ulcerative colitis (UC). However, the situations in which each marker should be used are largely unknown. Methods: A total of 110 colonoscopy intervals of UC patients were assessed, and correlations between changes in colonoscopic findings and changes in the two aforementioned fecal markers were examined. Results: Among patients with mucosal healing (MH) and negative FIT or Fcal results at the initial colonoscopy, FIT and Fcal findings exhibited accuracies of 93{\%} (38/41) and 79{\%} (26/33), respectively, for predicting the results of the subsequent examination. Among the 24 patients who showed endoscopic activity at the precedent colonoscopy and MH at the subsequent examination, positive-to-negative conversion of FIT and Fcal findings at the subsequent examination was observed in 92{\%} (12/13) and 62{\%} (8/13) of patients, respectively. Among the 43 patients who showed endoscopic activity at both the precedent and subsequent examinations, Fcal findings reflected the change in endoscopic activity better than FIT results (r=0.59, p<0.0001 vs r=0.30, p=0.054). Conclusions: The FIT is useful for confirming MH and the occurrence of relapse. In contrast, Fcal is useful for monitoring the mucosal status of patients with active inflammation. (Gut Liver 2018;12:142-148).",
keywords = "Colitis, Fecal calprotectin, Quantitative fecal immunochemical test, Ulcerative",
author = "Sakiko Hiraoka and Toshihiro Inokuchi and Asuka Nakarai and Shiho Takashima and Daisuke Takei and Yuusaku Sugihara and Masahiro Takahara and Keita Harada and Hiroyuki Okada and Jun Kato",
year = "2018",
month = "3",
day = "1",
doi = "10.5009/gnl17013",
language = "English",
volume = "12",
pages = "142--148",
journal = "Gut and Liver",
issn = "1976-2283",
publisher = "Joe Bok Chung",
number = "2",

}

TY - JOUR

T1 - Fecal immunochemical test and fecal calprotectin results show different profiles in disease monitoring for ulcerative colitis

AU - Hiraoka, Sakiko

AU - Inokuchi, Toshihiro

AU - Nakarai, Asuka

AU - Takashima, Shiho

AU - Takei, Daisuke

AU - Sugihara, Yuusaku

AU - Takahara, Masahiro

AU - Harada, Keita

AU - Okada, Hiroyuki

AU - Kato, Jun

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background/Aims: Both fecal immunochemical test (FIT) and fecal calprotectin (Fcal) results are useful biomarkers for ulcerative colitis (UC). However, the situations in which each marker should be used are largely unknown. Methods: A total of 110 colonoscopy intervals of UC patients were assessed, and correlations between changes in colonoscopic findings and changes in the two aforementioned fecal markers were examined. Results: Among patients with mucosal healing (MH) and negative FIT or Fcal results at the initial colonoscopy, FIT and Fcal findings exhibited accuracies of 93% (38/41) and 79% (26/33), respectively, for predicting the results of the subsequent examination. Among the 24 patients who showed endoscopic activity at the precedent colonoscopy and MH at the subsequent examination, positive-to-negative conversion of FIT and Fcal findings at the subsequent examination was observed in 92% (12/13) and 62% (8/13) of patients, respectively. Among the 43 patients who showed endoscopic activity at both the precedent and subsequent examinations, Fcal findings reflected the change in endoscopic activity better than FIT results (r=0.59, p<0.0001 vs r=0.30, p=0.054). Conclusions: The FIT is useful for confirming MH and the occurrence of relapse. In contrast, Fcal is useful for monitoring the mucosal status of patients with active inflammation. (Gut Liver 2018;12:142-148).

AB - Background/Aims: Both fecal immunochemical test (FIT) and fecal calprotectin (Fcal) results are useful biomarkers for ulcerative colitis (UC). However, the situations in which each marker should be used are largely unknown. Methods: A total of 110 colonoscopy intervals of UC patients were assessed, and correlations between changes in colonoscopic findings and changes in the two aforementioned fecal markers were examined. Results: Among patients with mucosal healing (MH) and negative FIT or Fcal results at the initial colonoscopy, FIT and Fcal findings exhibited accuracies of 93% (38/41) and 79% (26/33), respectively, for predicting the results of the subsequent examination. Among the 24 patients who showed endoscopic activity at the precedent colonoscopy and MH at the subsequent examination, positive-to-negative conversion of FIT and Fcal findings at the subsequent examination was observed in 92% (12/13) and 62% (8/13) of patients, respectively. Among the 43 patients who showed endoscopic activity at both the precedent and subsequent examinations, Fcal findings reflected the change in endoscopic activity better than FIT results (r=0.59, p<0.0001 vs r=0.30, p=0.054). Conclusions: The FIT is useful for confirming MH and the occurrence of relapse. In contrast, Fcal is useful for monitoring the mucosal status of patients with active inflammation. (Gut Liver 2018;12:142-148).

KW - Colitis

KW - Fecal calprotectin

KW - Quantitative fecal immunochemical test

KW - Ulcerative

UR - http://www.scopus.com/inward/record.url?scp=85045923934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045923934&partnerID=8YFLogxK

U2 - 10.5009/gnl17013

DO - 10.5009/gnl17013

M3 - Article

C2 - 28873508

AN - SCOPUS:85045923934

VL - 12

SP - 142

EP - 148

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - 2

ER -