TY - JOUR
T1 - Febrile neutropenia in a patient with non-small-cell lung cancer treated with atezolizumab
T2 - A case report
AU - Seguchi, Kyosuke
AU - Nakashima, Kei
AU - Terao, Toshiki
AU - Takeshita, Gaku
AU - Nagai, Tatsuya
AU - Tanaka, Yu
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/1
Y1 - 2021/1
N2 - Hematological immune-related adverse events (hem-irAEs) related to immunotherapy have not been extensively characterized, and there is no report of neutropenia caused by atezolizumab administration. Herein, we report a case of febrile neutropenia caused by a hem-irAEs due to atezolizumab, which was treated with granulocyte-colony stimulating factor (G-CSF) and antibiotic prophylaxis. It is important that oncologists be aware of the hematological toxicities of immune checkpoint inhibitors (ICIs). Furthermore, antibiotics and G-CSF should be administered until absolute neutrophil count recovery in cases of febrile neutropenia complicated by atezolizumab. Systemic corticosteroids should not be administered because they can accentuate the risk of infection.
AB - Hematological immune-related adverse events (hem-irAEs) related to immunotherapy have not been extensively characterized, and there is no report of neutropenia caused by atezolizumab administration. Herein, we report a case of febrile neutropenia caused by a hem-irAEs due to atezolizumab, which was treated with granulocyte-colony stimulating factor (G-CSF) and antibiotic prophylaxis. It is important that oncologists be aware of the hematological toxicities of immune checkpoint inhibitors (ICIs). Furthermore, antibiotics and G-CSF should be administered until absolute neutrophil count recovery in cases of febrile neutropenia complicated by atezolizumab. Systemic corticosteroids should not be administered because they can accentuate the risk of infection.
KW - Atezolizumab
KW - Hematologic immune-related adverse event
KW - Neutropenia
KW - Non-small-cell lung cancer
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U2 - 10.1016/j.rmcr.2021.101439
DO - 10.1016/j.rmcr.2021.101439
M3 - Article
AN - SCOPUS:85107264155
SN - 2213-0071
VL - 33
JO - Respiratory Medicine Case Reports
JF - Respiratory Medicine Case Reports
M1 - 101439
ER -
