Feasibility study of immediate pharyngeal cooling initiation in cardiac arrest patients after arrival at the emergency room

Yoshimasa Takeda, Takahisa Kawashima, Kazuya Kiyota, Shigeto Oda, Naoki Morimoto, Hitoshi Kobata, Hisashi Isobe, Mitsuru Honda, Satoshi Fujimi, Jun Onda, Seishi I, Tetsuya Sakamoto, Masami Ishikawa, Hiroshi Nakano, Daikai Sadamitsu, Masanobu Kishikawa, Kosaku Kinoshita, Tomoharu Yokoyama, Masahiro Harada, Michio Kitaura & 8 others Kiyoshi Ichihara, Hiroshi Hashimoto, Hidekazu Tsuji, Takashi Yorifuji, Osamu Nagano, Hiroshi Katayama, Yoshihito Ujike, Kiyoshi Morita

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: Cooling the pharynx and upper oesophagus would be more advantageous for rapid induction of therapeutic hypothermia since the carotid arteries run in their vicinity. The aim of this study was to determine the effects of pharyngeal cooling on brain temperature and the safety and feasibility for patients under resuscitation. Methods: Witnessed non-traumatic cardiac arrest patients (n=108) were randomized to receive standard care with (n=53) or without pharyngeal cooling (n=55). In the emergency room, pharyngeal cooling was initiated before or shortly after return of spontaneous circulation by perfusing physiological saline (5. °C) into a pharyngeal cuff for 120. min. Results: There was a significant decrease in tympanic temperature at 40. min after arrival (P=0.02) with a maximum difference between the groups at 120. min (32.9. ±. 1.2. °C, pharyngeal cooling group vs. 34.1. ±. 1.3. °C, control group; P

Original languageEnglish
Pages (from-to)1647-1653
Number of pages7
JournalResuscitation
Volume85
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Feasibility Studies
Heart Arrest
Hospital Emergency Service
Induced Hypothermia
Temperature
Patient Safety
Pharynx
Carotid Arteries
Resuscitation
Esophagus
Control Groups
Brain

Keywords

  • Brain ischaemia
  • Cardiac arrest
  • Intra-arrest cooling
  • Pharynx
  • Selective cooling
  • Therapeutic hypothermia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine
  • Medicine(all)

Cite this

Feasibility study of immediate pharyngeal cooling initiation in cardiac arrest patients after arrival at the emergency room. / Takeda, Yoshimasa; Kawashima, Takahisa; Kiyota, Kazuya; Oda, Shigeto; Morimoto, Naoki; Kobata, Hitoshi; Isobe, Hisashi; Honda, Mitsuru; Fujimi, Satoshi; Onda, Jun; I, Seishi; Sakamoto, Tetsuya; Ishikawa, Masami; Nakano, Hiroshi; Sadamitsu, Daikai; Kishikawa, Masanobu; Kinoshita, Kosaku; Yokoyama, Tomoharu; Harada, Masahiro; Kitaura, Michio; Ichihara, Kiyoshi; Hashimoto, Hiroshi; Tsuji, Hidekazu; Yorifuji, Takashi; Nagano, Osamu; Katayama, Hiroshi; Ujike, Yoshihito; Morita, Kiyoshi.

In: Resuscitation, Vol. 85, No. 12, 01.12.2014, p. 1647-1653.

Research output: Contribution to journalArticle

Takeda, Y, Kawashima, T, Kiyota, K, Oda, S, Morimoto, N, Kobata, H, Isobe, H, Honda, M, Fujimi, S, Onda, J, I, S, Sakamoto, T, Ishikawa, M, Nakano, H, Sadamitsu, D, Kishikawa, M, Kinoshita, K, Yokoyama, T, Harada, M, Kitaura, M, Ichihara, K, Hashimoto, H, Tsuji, H, Yorifuji, T, Nagano, O, Katayama, H, Ujike, Y & Morita, K 2014, 'Feasibility study of immediate pharyngeal cooling initiation in cardiac arrest patients after arrival at the emergency room', Resuscitation, vol. 85, no. 12, pp. 1647-1653. https://doi.org/10.1016/j.resuscitation.2014.09.014
Takeda, Yoshimasa ; Kawashima, Takahisa ; Kiyota, Kazuya ; Oda, Shigeto ; Morimoto, Naoki ; Kobata, Hitoshi ; Isobe, Hisashi ; Honda, Mitsuru ; Fujimi, Satoshi ; Onda, Jun ; I, Seishi ; Sakamoto, Tetsuya ; Ishikawa, Masami ; Nakano, Hiroshi ; Sadamitsu, Daikai ; Kishikawa, Masanobu ; Kinoshita, Kosaku ; Yokoyama, Tomoharu ; Harada, Masahiro ; Kitaura, Michio ; Ichihara, Kiyoshi ; Hashimoto, Hiroshi ; Tsuji, Hidekazu ; Yorifuji, Takashi ; Nagano, Osamu ; Katayama, Hiroshi ; Ujike, Yoshihito ; Morita, Kiyoshi. / Feasibility study of immediate pharyngeal cooling initiation in cardiac arrest patients after arrival at the emergency room. In: Resuscitation. 2014 ; Vol. 85, No. 12. pp. 1647-1653.
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AU - Morimoto, Naoki

AU - Kobata, Hitoshi

AU - Isobe, Hisashi

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AU - Fujimi, Satoshi

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AU - Ichihara, Kiyoshi

AU - Hashimoto, Hiroshi

AU - Tsuji, Hidekazu

AU - Yorifuji, Takashi

AU - Nagano, Osamu

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AU - Ujike, Yoshihito

AU - Morita, Kiyoshi

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