Feasibility of 18F-fluorodeoxyglucose positron-emission tomography for preoperative evaluation of biliary tract cancer

Isamu Yamada, Tetsuo Ajiki, Kimihiko Ueno, Hidehiro Sawa, Izuru Otsubo, Yuko Yoshida, Makoto Shinzeki, Hirochika Toyama, Ippei Matsumoto, Takumi Fukumoto, Atsunori Nakao, Joji Kotani, Yonson Ku

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

18F-Labeled fluorodeoxyglucose positron-emission tomography (FDG-PET), a rapidly evolving functional imaging modality, has recently been shown to be useful in the diagnosis and staging of various malignant tumors due to focal uptake of FDG-labeled glucose in malignant cell populations. However, the role of FDG-PET in the diagnosis and staging of biliary tract cancer is still controversial and has not yet been fully evaluated. The aim of this study was to determine the clinical importance of FDG-PET in the preoperative evaluation of biliary tract cancer and retrospectively clarify the characteristics of false-negative and false-positive cases. We retrospectively analyzed data for 73 consecutive patients diagnosed with cancer of the biliary tract and were admitted to the Department of Hepato-Biliary-Pancreatic Surgery at Kobe University Hospital for treatment, from January 2007 to August 2009. Since the sensitivity, specificity and positive predictive value (PPV) of FDG-PET in the diagnosis of bile duct carcinoma are usually relatively high, FDG-PET is considered to be a useful tool in diagnosing biliary tract cancer. FDG-PET also seems to be useful in clinical decision-making, regarding treatment strategy, including surgery. Our results showed that FDG-PET is highly sensitive in delineating the primary focus of biliary cancer and is a useful tool in preoperative examination. A disadvantage of FDG-PET is its inability to indicate small metastases and false-positive findings of inflamed gallbladder and bile duct lesions.

Original languageEnglish
Pages (from-to)5105-5110
Number of pages6
JournalAnticancer research
Volume32
Issue number11
Publication statusPublished - Nov 2012

Keywords

  • Bile duct cancer
  • F-labeled fluorodeoxyglucose positron-emission tomography
  • False-positive
  • Inflammation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Yamada, I., Ajiki, T., Ueno, K., Sawa, H., Otsubo, I., Yoshida, Y., Shinzeki, M., Toyama, H., Matsumoto, I., Fukumoto, T., Nakao, A., Kotani, J., & Ku, Y. (2012). Feasibility of 18F-fluorodeoxyglucose positron-emission tomography for preoperative evaluation of biliary tract cancer. Anticancer research, 32(11), 5105-5110.