Feasibility of repairing defects followed by treatment with pulmonary hypertension-specific drugs (repair and treat) in patients with pulmonary hypertension associated with atrial septal defect: Study protocol for interventional trial

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Abstract

A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalActa medica Okayama
Volume70
Issue number5
Publication statusPublished - 2016

Keywords

  • Atrial septal defect
  • Pulmonary hypertension
  • Repair and treat
  • Transcatheter closure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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