Abstract
BACKGROUND. Radiofrequency ablation (RFA) has become an accepted alternative for treating intrathoracic malignancies; however, the incidence and characteristics of peri- and postprocedural complications are not well described. The purpose of the study was to assess the safety and technical feasibility of percutaneous RFA in unresectable intrathoracic malignancies. METHODS. Percutaneous RFA was performed in patients with intrathoracic malignancies between June 2001 and December 2004. In total, 366 tumors were treated in 137 patients in 211 sessions. All patients were nonsurgical candidates or had refused surgery. Three hundred and thirty-six lesions were subjected to RFA for the treatment of metastases and 30 lesions for primary lung carcinoma. RESULTS. Although no procedural mortality occurred, 2 patients died during the course of the study because of intractable pneumothorax and massive hemoptysis (0.9%). The overall major complication rate was 17.1% (pneumothoraces requiring tube drainage in 25, pleuritis in 6, pleural effusion requiring tube drainage in 4, lung abscess in 1, and intrapulmonary hemorrhage with hemothorax in 1). Minor complications included pneumothoraces not requiring tube drainage in 108 sessions, pleural effusion without drainage in 34, hemosputum in 9, nausea and/or vomiting in 3, subcutaneous emphysema in 3, cough in 2, skin burn in 2, atelectasis in 1, and subileus in 1. High fever and/or chest pain were seen in 33.8% and 39.3% of patients, respectively. CONCLUSIONS. With over 200 procedures, RFA appears to be a safe and minimally invasive option with negligible mortality and little morbidity in selected patients with unresectable intrathoracic malignancies.
| Original language | English |
|---|---|
| Pages (from-to) | 1397-1405 |
| Number of pages | 9 |
| Journal | Cancer |
| Volume | 109 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Apr 1 2007 |
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Keywords
- Complications
- Intrathoracic malignancy
- Lung cancer
- Lung metastasis
- Radiofrequency ablation
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Feasibility of percutaneous radiofrequency ablation for intrathoracic malignancies : A large single-center experience. / Sano, Yoshifumi; Kanazawa, Susumu; Gobara, Hideo; Mukai, Takashi; Hiraki, Takao; Hase, Soichiro; Toyooka, Shinichi; Aoe, Motoi; Date, Hiroshi.
In: Cancer, Vol. 109, No. 7, 01.04.2007, p. 1397-1405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Feasibility of percutaneous radiofrequency ablation for intrathoracic malignancies
T2 - A large single-center experience
AU - Sano, Yoshifumi
AU - Kanazawa, Susumu
AU - Gobara, Hideo
AU - Mukai, Takashi
AU - Hiraki, Takao
AU - Hase, Soichiro
AU - Toyooka, Shinichi
AU - Aoe, Motoi
AU - Date, Hiroshi
PY - 2007/4/1
Y1 - 2007/4/1
N2 - BACKGROUND. Radiofrequency ablation (RFA) has become an accepted alternative for treating intrathoracic malignancies; however, the incidence and characteristics of peri- and postprocedural complications are not well described. The purpose of the study was to assess the safety and technical feasibility of percutaneous RFA in unresectable intrathoracic malignancies. METHODS. Percutaneous RFA was performed in patients with intrathoracic malignancies between June 2001 and December 2004. In total, 366 tumors were treated in 137 patients in 211 sessions. All patients were nonsurgical candidates or had refused surgery. Three hundred and thirty-six lesions were subjected to RFA for the treatment of metastases and 30 lesions for primary lung carcinoma. RESULTS. Although no procedural mortality occurred, 2 patients died during the course of the study because of intractable pneumothorax and massive hemoptysis (0.9%). The overall major complication rate was 17.1% (pneumothoraces requiring tube drainage in 25, pleuritis in 6, pleural effusion requiring tube drainage in 4, lung abscess in 1, and intrapulmonary hemorrhage with hemothorax in 1). Minor complications included pneumothoraces not requiring tube drainage in 108 sessions, pleural effusion without drainage in 34, hemosputum in 9, nausea and/or vomiting in 3, subcutaneous emphysema in 3, cough in 2, skin burn in 2, atelectasis in 1, and subileus in 1. High fever and/or chest pain were seen in 33.8% and 39.3% of patients, respectively. CONCLUSIONS. With over 200 procedures, RFA appears to be a safe and minimally invasive option with negligible mortality and little morbidity in selected patients with unresectable intrathoracic malignancies.
AB - BACKGROUND. Radiofrequency ablation (RFA) has become an accepted alternative for treating intrathoracic malignancies; however, the incidence and characteristics of peri- and postprocedural complications are not well described. The purpose of the study was to assess the safety and technical feasibility of percutaneous RFA in unresectable intrathoracic malignancies. METHODS. Percutaneous RFA was performed in patients with intrathoracic malignancies between June 2001 and December 2004. In total, 366 tumors were treated in 137 patients in 211 sessions. All patients were nonsurgical candidates or had refused surgery. Three hundred and thirty-six lesions were subjected to RFA for the treatment of metastases and 30 lesions for primary lung carcinoma. RESULTS. Although no procedural mortality occurred, 2 patients died during the course of the study because of intractable pneumothorax and massive hemoptysis (0.9%). The overall major complication rate was 17.1% (pneumothoraces requiring tube drainage in 25, pleuritis in 6, pleural effusion requiring tube drainage in 4, lung abscess in 1, and intrapulmonary hemorrhage with hemothorax in 1). Minor complications included pneumothoraces not requiring tube drainage in 108 sessions, pleural effusion without drainage in 34, hemosputum in 9, nausea and/or vomiting in 3, subcutaneous emphysema in 3, cough in 2, skin burn in 2, atelectasis in 1, and subileus in 1. High fever and/or chest pain were seen in 33.8% and 39.3% of patients, respectively. CONCLUSIONS. With over 200 procedures, RFA appears to be a safe and minimally invasive option with negligible mortality and little morbidity in selected patients with unresectable intrathoracic malignancies.
KW - Complications
KW - Intrathoracic malignancy
KW - Lung cancer
KW - Lung metastasis
KW - Radiofrequency ablation
UR - http://www.scopus.com/inward/record.url?scp=33947492612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947492612&partnerID=8YFLogxK
U2 - 10.1002/cncr.22541
DO - 10.1002/cncr.22541
M3 - Article
C2 - 17315166
AN - SCOPUS:33947492612
VL - 109
SP - 1397
EP - 1405
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 7
ER -