Feasibility of lung transplantation from donors mechanically ventilated for prolonged periods

Seiichiro Sugimoto, Takeshi Kurosaki, Shinji Otani, Shin Tanaka, Yukiko Hikasa, Masaomi Yamane, Shinichi Toyooka, Motomu Kobayashi, Takahiro Oto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Purpose: When patients are mechanically ventilated for more than 5 days, they are usually declined as donors for lung transplantation (LTx); thus, the long-term outcomes of LTx from such donors remain unclear. We investigated the feasibility of LTx from donors that had been mechanically ventilated for prolonged periods. Methods: The subjects of this retrospective comparative investigation were 31 recipients of LTx from donors who had been mechanically ventilated for < 5 days (short-term group) and 50 recipients of LTx from donors who had been mechanically ventilated for ≥ 5 days (long-term group). Results: The median duration of donor mechanical ventilation was 3 days in the short-term group and 8.5 days in the long-term group. However, other than the difference in the duration of donor ventilation, there were no significant differences in the clinical characteristics of the donors or recipients between the groups. The overall survival rate after LTx was comparable between the long-term group and short-term group (5-year survival rate, 66.6% vs. 75.2%). Conclusion: The potential inclusion of donors who have been on mechanical ventilation for more than 5 days could be a feasible strategy to alleviate donor organ shortage.

Original languageEnglish
Pages (from-to)254-260
Number of pages7
JournalSurgery today
Volume49
Issue number3
DOIs
Publication statusPublished - Mar 8 2019

Keywords

  • Brain-dead donor
  • Extended-criteria donor
  • Lung transplantation
  • Marginal donor
  • Mechanical ventilation

ASJC Scopus subject areas

  • Surgery

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