Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support

Katsuhiro Ohuchi, Hideo Hoshi, Yasuhiko Iwasaki, Kazuhiko Ishihara, Masaharu Yoshikawa, Shinya Ugaki, Kozo Ishino, Satoru Osaki, Yasuhiro Kotani, Shunji Sano, Setsuo Takatani

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this study, the performances of the TinyPump (priming volume 5 mL) system including the pediatric cannulae (Stöckert Pediatric Arterial Cannulae 2.6, 3.0, and 4.0 mm, Stöckert Instruments GmbH, Munich, Germany; Polystan 20-Fr Venous Catheter, MAQUET GmbH, Rastatt, Germany) and an oxygenator (Terumo Capiox RX05 Baby-RX, Terumo Cardiovascular Systems Co., Tokyo, Japan) were studied in vitro followed with preliminary ex vivo studies in 20-kg piglets. In vitro results revealed that the TinyPump system met the requirements for pump speed, pump flow, and pressure drop as extracorporeal circulatory support during open heart surgery and extracorporeal membrane oxygenation (ECMO) in pediatric patients. In 2-h ex vivo studies using 20-kg piglets where the blood contacting surface of the TinyPump was coated with a biocompatible phospholipid polymer, the plasma-free hemoglobin levels remained less than 5.0 mg/dL and no thrombus formation was observed inside the pump. The TinyPump system including the oxygenator and connecting circuits resulted in an overall priming volume of 68 mL, the smallest ever reported. The TinyPump can be a safe option for pediatric circulatory support during open heart surgery and ECMO without requiring blood transfusion.

Original languageEnglish
Pages (from-to)408-412
Number of pages5
JournalArtificial Organs
Volume31
Issue number5
DOIs
Publication statusPublished - May 2007

Fingerprint

Pediatrics
Blood
Pumps
Oxygenators
Extracorporeal Membrane Oxygenation
Thoracic Surgery
Oxygenation
Germany
Surgery
Tokyo
Cardiovascular System
Membranes
Cardiovascular system
Blood Transfusion
Catheters
Hemoglobin
Phospholipids
Japan
Polymers
Hemoglobins

Keywords

  • Cardiopulmonary bypass
  • Centrifugal blood pump
  • Extracorporeal membrane oxygenation
  • Pediatric circulatory support
  • Ventricular assist device

ASJC Scopus subject areas

  • Biophysics

Cite this

Ohuchi, K., Hoshi, H., Iwasaki, Y., Ishihara, K., Yoshikawa, M., Ugaki, S., ... Takatani, S. (2007). Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support. Artificial Organs, 31(5), 408-412. https://doi.org/10.1111/j.1525-1594.2007.00401.x

Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support. / Ohuchi, Katsuhiro; Hoshi, Hideo; Iwasaki, Yasuhiko; Ishihara, Kazuhiko; Yoshikawa, Masaharu; Ugaki, Shinya; Ishino, Kozo; Osaki, Satoru; Kotani, Yasuhiro; Sano, Shunji; Takatani, Setsuo.

In: Artificial Organs, Vol. 31, No. 5, 05.2007, p. 408-412.

Research output: Contribution to journalArticle

Ohuchi, K, Hoshi, H, Iwasaki, Y, Ishihara, K, Yoshikawa, M, Ugaki, S, Ishino, K, Osaki, S, Kotani, Y, Sano, S & Takatani, S 2007, 'Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support', Artificial Organs, vol. 31, no. 5, pp. 408-412. https://doi.org/10.1111/j.1525-1594.2007.00401.x
Ohuchi, Katsuhiro ; Hoshi, Hideo ; Iwasaki, Yasuhiko ; Ishihara, Kazuhiko ; Yoshikawa, Masaharu ; Ugaki, Shinya ; Ishino, Kozo ; Osaki, Satoru ; Kotani, Yasuhiro ; Sano, Shunji ; Takatani, Setsuo. / Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support. In: Artificial Organs. 2007 ; Vol. 31, No. 5. pp. 408-412.
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