Favorable response of heavily treated Wilms' tumor to paclitaxel and carboplatin

Saeko Ozaki, Nagio Takigawa, Eiki Ichihara, Katsuyuki Hotta, Isao Oze, Etsuko Kurimoto, Soichiro Fushimi, Tetsuya Ogino, Masahiro Tabata, Mitsune Tanimoto, Katsuyuki Kiura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Heavily treated Wilms' tumor responding to the combination of paclitaxel and carboplatin has not yet been reported. Case Report: A 17-year-old man presented with hematuria. He received a diagnosis of Wilms' tumor with multiple lung metastases and was treated with preoperative chemotherapy including vincristine, dactinomycin, and doxorubicin, a right nephrectomy, and adjuvant chemotherapy, followed by pulmonary metastasectomy. During the next 8 years, he suffered from 4 relapses and has been treated with multiple anticancer agents including high-dose chemotherapy with autologous peripheral blood stem cell transplantation. Finally, the disease progressed due to peritoneal and pleural metastases. With opioid administration for left shoulder pain due to pleural metastasis, he received combination chemotherapy with carboplatin (area under the curve = 4) and paclitaxel (175 mg/m2) on day 1. After 2 cycles, he achieved a partial response with mild toxicity. He received 7 cycles of the chemotherapy and the time to progression was 200 days. Conclusion: In a refractory case after intensive treatments, we succeeded to control the disease for a while.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalOnkologie
Volume35
Issue number5
DOIs
Publication statusPublished - May 2012

Fingerprint

Wilms Tumor
Carboplatin
Paclitaxel
Neoplasm Metastasis
Drug Therapy
Metastasectomy
A 17
Peripheral Blood Stem Cell Transplantation
Lung
Shoulder Pain
Dactinomycin
Vincristine
Hematuria
Adjuvant Chemotherapy
Combination Drug Therapy
Nephrectomy
Antineoplastic Agents
Doxorubicin
Opioid Analgesics
Area Under Curve

Keywords

  • Carboplatin
  • Chemotherapy
  • Paclitaxel
  • Recurrence
  • Wilms' tumor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Hematology

Cite this

Favorable response of heavily treated Wilms' tumor to paclitaxel and carboplatin. / Ozaki, Saeko; Takigawa, Nagio; Ichihara, Eiki; Hotta, Katsuyuki; Oze, Isao; Kurimoto, Etsuko; Fushimi, Soichiro; Ogino, Tetsuya; Tabata, Masahiro; Tanimoto, Mitsune; Kiura, Katsuyuki.

In: Onkologie, Vol. 35, No. 5, 05.2012, p. 283-286.

Research output: Contribution to journalArticle

Ozaki, S, Takigawa, N, Ichihara, E, Hotta, K, Oze, I, Kurimoto, E, Fushimi, S, Ogino, T, Tabata, M, Tanimoto, M & Kiura, K 2012, 'Favorable response of heavily treated Wilms' tumor to paclitaxel and carboplatin', Onkologie, vol. 35, no. 5, pp. 283-286. https://doi.org/10.1159/000338532
Ozaki, Saeko ; Takigawa, Nagio ; Ichihara, Eiki ; Hotta, Katsuyuki ; Oze, Isao ; Kurimoto, Etsuko ; Fushimi, Soichiro ; Ogino, Tetsuya ; Tabata, Masahiro ; Tanimoto, Mitsune ; Kiura, Katsuyuki. / Favorable response of heavily treated Wilms' tumor to paclitaxel and carboplatin. In: Onkologie. 2012 ; Vol. 35, No. 5. pp. 283-286.
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