Favorable outcomes after living-donor lobar lung transplantation in ventilator-dependent patients

Shinichi Toyooka, Masaomi Yamane, Takahiro Oto, Yoshifumi Sano, Megumi Okazaki, Motohiko Hanazaki, Keiji Goto, Hiroshi Date

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose. Living-donor lobar lung transplantation (LDLLT) is performed in critically ill patients, although the outcome is generally expected to be poor for those who are ventilator dependent. The aim of this study was to compare the outcomes of LDLLT in ventilator-dependent patients compared with those in ventilator-independent patients. Methods. We reviewed 31 consecutive patients who received LDLLT between October 1998 and May 2004. Results. Five patients were ventilator dependent and 26 were ventilator independent. All five ventilator-dependent patients were female, with a mean age of 29.6 years. The duration of preoperative ventilation was 23.4 ± 5.7 days. The underlying diagnoses in the ventilator-dependent patients included only obstructive (n = 3) and infectious lung diseases (n = 2), whereas those in the ventilator- independent patients included hypertensive and restrictive diseases (P = 0.004). There were no significant differences between the groups in early postoperative clinical values. The incidences of acute rejection and bronchiolitis obliterans syndrome (BOS) were comparable. The 5-year survival rates were 100% for the ventilator-dependent patients and 92.3% for the ventilator-independent patients (P = 0.45). Conclusion. Our findings suggest that LDLLT can have a favorable outcome in selected ventilator-dependent patients.

Original languageEnglish
Pages (from-to)1078-1082
Number of pages5
JournalSurgery Today
Volume38
Issue number12
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Lung Transplantation
Living Donors
Mechanical Ventilators
Bronchiolitis Obliterans
Critical Illness
Lung Diseases
Communicable Diseases
Ventilation
Survival Rate

Keywords

  • Complication
  • Living-donor lobar lung transplantation
  • Prognosis
  • Ventilator

ASJC Scopus subject areas

  • Surgery

Cite this

Favorable outcomes after living-donor lobar lung transplantation in ventilator-dependent patients. / Toyooka, Shinichi; Yamane, Masaomi; Oto, Takahiro; Sano, Yoshifumi; Okazaki, Megumi; Hanazaki, Motohiko; Goto, Keiji; Date, Hiroshi.

In: Surgery Today, Vol. 38, No. 12, 12.2008, p. 1078-1082.

Research output: Contribution to journalArticle

Toyooka, Shinichi ; Yamane, Masaomi ; Oto, Takahiro ; Sano, Yoshifumi ; Okazaki, Megumi ; Hanazaki, Motohiko ; Goto, Keiji ; Date, Hiroshi. / Favorable outcomes after living-donor lobar lung transplantation in ventilator-dependent patients. In: Surgery Today. 2008 ; Vol. 38, No. 12. pp. 1078-1082.
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abstract = "Purpose. Living-donor lobar lung transplantation (LDLLT) is performed in critically ill patients, although the outcome is generally expected to be poor for those who are ventilator dependent. The aim of this study was to compare the outcomes of LDLLT in ventilator-dependent patients compared with those in ventilator-independent patients. Methods. We reviewed 31 consecutive patients who received LDLLT between October 1998 and May 2004. Results. Five patients were ventilator dependent and 26 were ventilator independent. All five ventilator-dependent patients were female, with a mean age of 29.6 years. The duration of preoperative ventilation was 23.4 ± 5.7 days. The underlying diagnoses in the ventilator-dependent patients included only obstructive (n = 3) and infectious lung diseases (n = 2), whereas those in the ventilator- independent patients included hypertensive and restrictive diseases (P = 0.004). There were no significant differences between the groups in early postoperative clinical values. The incidences of acute rejection and bronchiolitis obliterans syndrome (BOS) were comparable. The 5-year survival rates were 100{\%} for the ventilator-dependent patients and 92.3{\%} for the ventilator-independent patients (P = 0.45). Conclusion. Our findings suggest that LDLLT can have a favorable outcome in selected ventilator-dependent patients.",
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