Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders

Yukiko Nitta, Keiji Iwatsuki, Hiroshi Kimura, Seiji Kojima, Tsuneo Moroshima, Kazuhide Tsuji, Takashi Oono

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23 Citations (Scopus)

Abstract

Natural killer (NK) lymphoma in Asia is frequently associated with latent Epstein-Barr (EBV) infection. Unlike the adult cases, EBV-associated NK/T cell lymphomas in children are often preceded by various EBV-related disorders, including chronic active EBV infection (CAEBV), hypersensitivity to mosquito bites (HMB), virus-associated haemophagocytic syndrome (VAHS), and hydroa vacciniforme (HV)like eruptions. Here, we report a 14-year-old Japanese girl who sequentially developed all the symptoms related to EBV-associated NK/T cell lymphoproliferative disorders in a 12-year clinical course. Our observations confirm the spectrum of EBV-associated cutaneous disorders and indicate the importance of long-term follow-up.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalEuropean Journal of Dermatology
Volume15
Issue number6
Publication statusPublished - Nov 2005

Keywords

  • EB virus
  • Haemophagocytosis
  • Hydroa vacciniforme
  • Mosquito bite
  • Nasal lymphoma
  • Natural killer cell

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Nitta, Y., Iwatsuki, K., Kimura, H., Kojima, S., Moroshima, T., Tsuji, K., & Oono, T. (2005). Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders. European Journal of Dermatology, 15(6), 503-506.